Inference of gene regulation via miRNAs during ES cell differentiation using MiRaGE method.
Inference of gene regulation via miRNAs during ES cell differentiation using MiRaGE method.
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DOI:
10.3390/ijms12129265
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发表时间:
2011
影响因子:
5.6
通讯作者:
Yasuda J
中科院分区:
文献类型:
--
作者:
Yoshizawa M;Taguchi YH;Yasuda J
MicroRNA (miRNA) is a critical regulator of cell growth, differentiation, and development. To identify important miRNAs in a biological process, many bioinformatical tools have been developed. We have developed MiRaGE (MiRNA Ranking by Gene Expression) method to infer the regulation of gene expression by miRNAs from changes of gene expression profiles. The method does not require precedent array normalization. We applied the method to elucidate possibly important miRNAs during embryonic stem (ES) cell differentiation to neuronal cells and we infer that certain miRNAs, including miR-200 family, miR-429, miR-302 family, and miR-17-92 cluster members may be important to the maintenance of undifferentiated status in ES cells.
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DOI:
10.1111/j.2517-6161.1995.tb02031.x
发表时间:
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影响因子:
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作者:
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