Overreactive brain responses to sensory stimuli in youth with autism spectrum disorders.
Overreactive brain responses to sensory stimuli in youth with autism spectrum disorders.
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DOI：
10.1016/j.jaac.2013.08.004
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发表时间：
2013-11
影响因子：
13.3
通讯作者：
Bookheimer, Susan Y.
中科院分区：
文献类型：
--
作者：
Green, Shulamite A.;Rudie, Jeffrey D.;Colich, Natalie L.;Wood, Jeffrey J.;Shirinyan, David;Hernandez, Leanna;Tottenham, Nim;Dapretto, Mirella;Bookheimer, Susan Y.
关键词：
感觉过度反应（SOR），定义为对感觉刺激的负面反应或回避，在患有自闭症谱系障碍（ASD）的青少年中非常普遍和严重损害，但对SOR的神经基础知之甚少。本研究旨在通过比较患有和没有ASD的青年对感觉刺激的大脑反应来检查SOR的功能神经相关性。在功能性磁共振成像（fMRI）扫描过程中，25名患有ASD的高功能青年和25名年龄和智商相当的典型发育（TD）青年接受了轻度厌恶的听觉和视觉刺激。父母提供了儿童的SOR和焦虑症状的严重程度的评级。与TD参与者相比，ASD参与者在初级感觉皮层区域以及杏仁核，海马和眶额皮层显示出更大的激活。在这两组中，这些区域的活动水平与父母评定的SOR严重程度呈正相关，高于焦虑行为评分。这项研究表明，青少年与ASD显示神经超反应的感觉刺激，和SOR的行为症状可能与两个提高反应在初级感觉区域以及相关的区域的情绪处理，和调节。
Sensory over-responsivity (SOR), defined as a negative response to or avoidance of sensory stimuli, is both highly prevalent and extremely impairing in youth with autism spectrum disorders (ASD), yet little is known about the neurological bases of SOR. This study aimed to examine the functional neural correlates of SOR by comparing brain responses to sensory stimuli in youth with and without ASD. Twenty-five high-functioning youth with ASD and 25 age- and IQ-equivalent typically developing (TD) youth were presented with mildly aversive auditory and visual stimuli during a functional magnetic resonance imaging (fMRI) scan. Parents provided ratings of children's SOR and anxiety symptom severity. Compared to TD participants, ASD participants displayed greater activation in primary sensory cortical areas as well as amygdala, hippocampus, and orbital-frontal cortex. In both groups, the level of activity in these areas was positively correlated with level of SOR severity as rated by parents, over and above behavioral ratings of anxiety. This study demonstrates that youth with ASD show neural hyper-responsivity to sensory stimuli, and that behavioral symptoms of SOR may be related to both heightened responsivity in primary sensory regions as well as areas related to emotion processing, and regulation.
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