Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease.
Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease.
复制标题
DOI：
10.1111/j.1365-2982.2008.01256.x
复制
发表时间：
2009-02
影响因子：
3.5
通讯作者：
Enomoto H
中科院分区：
文献类型：
--
作者：
Burzynski G;Shepherd IT;Enomoto H
肠神经系统是周围神经系统中最大、最复杂的分支。它的作用是调节胃肠道（GI）的许多功能所必需的，包括其运动性。虽然ENS已经被发育生物学家、神经科学家和生理学家广泛研究了几十年，但直到20世纪90年代初，ENS发育的分子和遗传基础才开始出现。这种理解的核心是使用遗传模式生物。在这篇文章中，我们将讨论最近的进展，已经取得了使用小鼠和斑马鱼模型遗传系统，导致新的见解ENS的发展和先天性巨结肠症的遗传基础。
The enteric nervous system (ENS) is the largest and most complicated subdivison of the peripheral nervous system. Its action is necessary to regulate many of the functions of the gastrointestinal (GI) tract including its motility. Whilst the ENS has been studied extensively by developmental biologists, neuroscientists and physiologists for several decades it has only been since the early 1990's that the molecular and genetic basis of ENS development has begun to emerge. Central to this understanding has been the use of genetic model organisms. In this article we will discuss recent advances that have been achieved using both mouse and zebrafish model genetic systems that have led to new insights into ENS development and the genetic basis of Hirschsprung's Disease.
登录
查看更多内容
影响因子：
6
作者：
Carniti, C;Belluco, S;Bongarzone, I
通讯作者：
Bongarzone, I
影响因子：
2.7
作者：
CSERJESI, P;BROWN, D;OLSON, EN
通讯作者：
OLSON, EN
影响因子：
30.8
作者：
Carrasquillo, MM;McCallion, AS;Chakravarti, A
通讯作者：
Chakravarti, A
影响因子：
4.5
作者：
Antonellis, Anthony;Huynh, Jimmy L.;Lee-Lin, Shih-Queen;Vinton, Ryan M.;Renaud, Gabriel;Loftus, Stacie K.;Elliot, Gene;Wolfsberg, Tyra G.;Green, Eric D.;McCallion, Andrew S.;Pavan, William J.
通讯作者：
Pavan, William J.
影响因子：
5.3
作者：
Baudet, Christel;Pozas, Ester;Ernfors, Patrik
通讯作者：
Ernfors, Patrik