Prediction of post-TACE necrosis of hepatocellular carcinoma usingvolumetric enhancement on MRI and volumetric oil deposition on CT, with pathological correlation.
Prediction of post-TACE necrosis of hepatocellular carcinoma usingvolumetric enhancement on MRI and volumetric oil deposition on CT, with pathological correlation.
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DOI：
10.1007/s00330-017-5198-9
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发表时间：
2018-07
影响因子：
5.9
通讯作者：
Kamel IR
中科院分区：
文献类型：
--
作者：
Najmi Varzaneh F;Pandey A;Aliyari Ghasabeh M;Shao N;Khoshpouri P;Pandey P;Zarghampour M;Fouladi D;Liddell R;Anders RA;Kamel IR
研究基线MRI上的体积增强和未增强CT上的体积油沉积是否可以预测HCC坏死和TACE后的反应。在接受cTACE的115例回顾性HCC患者（173处病变）中，53例HCC患者接受了肝移植（LT）。在双重成像上进行靶病变的半自动体积分割，以评估整个队列和LT组中TACE后肿瘤坏死预测的准确性。预测的肿瘤坏死百分比定义为100%-（基线MRI增强%-CT油沉积%）。通过双重成像模式预测的平均肿瘤坏死率为61.5% ± 31.6%;随访MRI的平均肿瘤坏死百分比为63.8% ± 31.5%。在LT组中，双成像模式预测的平均肿瘤坏死率为77.6% ± 27.2。%;病理学平均坏死百分比为78.7% ± 31.5%。在MRI随访中预测的肿瘤坏死和体积坏死之间（r = 0.889，p<0.001）以及预测的肿瘤坏死和病理性坏死之间（r = 0.871，p<0.001）有很强的显著相关性。MRI上TACE前的体积增强和CT上TACE后的油沉积可以准确预测治疗的HCC病变的坏死。
To investigate whether volumetric enhancement on baseline MRI and volumetric oil deposition on unenhanced CT would predict HCC necrosis and response post-TACE. Of 115 retrospective HCC patients (173 lesions) who underwent cTACE, a subset of 53 HCC patients underwent liver transplant (LT). Semiautomatic volumetric segmentation of target lesions was performed on dual imaging to assess the accuracy of predicting tumour necrosis after TACE in the whole cohort and at pathology in the LT group. Predicted percentage tumour necrosis is defined as 100 % - (%baseline MRI enhancement - %CT oil deposition). Mean predicted tumour necrosis by dual imaging modalities was 61.5 % ± 31.6%; mean percentage tumour necrosis on follow-up MRI was 63.8 % ± 31.5 %. In the LT group, mean predicted tumour necrosis by dual imaging modalities was 77.6 % ± 27.2. %; mean percentage necrosis at pathology was 78.7 % ± 31.5 %. There was a strong significant correlation between predicted tumour necrosis and volumetric necrosis on MRI follow-up (r = 0.889, p<0.001) and between predicted tumour necrosis and pathological necrosis (r = 0.871, p<0.001). Volumetric pre-TACE enhancement on MRI and post-TACE oil deposition in CT may accurately predict necrosis in treated HCC lesions.
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影响因子：
3.2
作者：
Valero, Vicente, III;Amini, Neda;Spolverato, Gaya;Weiss, Matthew J.;Hirose, Kenzo;Dagher, Nabil N.;Wolfgang, Christopher L.;Cameron, Andrew A.;Philosophe, Benjamin;Kamel, Ihab R.;Pawlik, Timothy M.
通讯作者：
Pawlik, Timothy M.
DOI：
10.4103/0971-3026.155835
发表时间：
2015-04
期刊：
The Indian journal of radiology & imaging
影响因子：
--
作者：
Hayano K;Lee SH;Sahani DV
通讯作者：
Sahani DV
影响因子：
6.4
作者：
Bray, F.;Ferlay, J.;Forman, D.
通讯作者：
Forman, D.
影响因子：
4.6
作者：
Kwan, Sharon W.;Fidelman, Nicholas;Yao, Francis Y.
通讯作者：
Yao, Francis Y.
影响因子：
5
作者：
Monsky, Wayne L.;Kim, Isaac;Badawi, Ramsey D.
通讯作者：
Badawi, Ramsey D.