Swallowing Pressure Variability as a Function of Pharyngeal Region, Bolus Volume, Age, and Sex.
Swallowing Pressure Variability as a Function of Pharyngeal Region, Bolus Volume, Age, and Sex.
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DOI：
10.1002/lary.28667
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
McCulloch TM
中科院分区：
文献类型：
--
作者：
Jones CA;Ciucci MR;Abdelhalim SM;McCulloch TM
个体内运动变异性发生在大多数运动域。然而，目前尚不清楚健康个体的咽部吞咽压力如何变化。我们假设：1）咽部区域之间的变异性不同; 2）变异性随着推注体积的增加而降低; 3）变异性随着年龄的增加而增加; 4）没有性别差异。我们使用咽部高分辨率测压来测量以下区域的吞咽压力：咽喉部、舌根、下咽部和上食管括约肌（UES）。数据收集自97名21-89岁的健康成人（41名男性），在稀液体吞咽期间：2 mL、10 mL和参与者选择的舒适体积。使用变异系数测量压力变异性。重复测量ANOVA用于评估区域、推注体积、年龄和性别对压力变异性的影响。有一个显着的区域×体积的相互作用（p<0.001）和显着的年龄的主效应（p=0.005）。下咽部区域的压力比所有其他区域的变化更大（p≤0.028），舌根区域的压力比所有其他区域的变化更小（p≤0.002），但2 ml体积除外（p=0.065）。咽部和UES区域的吞咽压力变异性显著不同，舒适体积和2 ml吞咽的变异性大于10 ml吞咽（p≤0.026）。压力变异性随着年龄的增加而显著增加（p=0.002）。性别对压力变异性无影响（p≥0.15）。咽部吞咽压力的变异性根据咽部区域、体积和年龄而不同，但与性别无关。异常的吞咽压力变异性可能反映了吞咽障碍患者的运动控制偏差，本研究的结果可用作未来评估吞咽压力产生的研究的规范性数据。
Within-individual movement variability occurs in most motor domains. However, it is unknown how pharyngeal swallowing pressure varies in healthy individuals. We hypothesized that: 1) variability would differ among pharyngeal regions; 2) variability would decrease with increased bolus volume; 3) variability would increase with age; and 4) there would be no sex differences. We used pharyngeal high-resolution manometry to measure swallowing pressure in the following regions: velopharynx, tongue base, hypopharynx, and upper esophageal sphincter (UES). Data were collected from 97 healthy adults (41 male) age 21–89 during thin liquid swallows: 2mL, 10mL, and participant-selected comfortable volume. Pressure variability was measured using coefficient of variation. Repeated measures ANOVA was used to assess impacts of region, bolus volume, age, and sex on pressure variability. There was a significant region×volume interaction (p<0.001) and significant main effect of age (p=0.005). Pressures in the hypopharynx region were more variable than all other regions (p≤0.028), and pressures in the tongue base region were less variable than all other regions (p≤0.002), except at 2ml volumes (p=0.065). Swallowing pressure variability was significantly different in the velopharynx and UES regions, with comfortable volume and 2ml swallows having greater variability than 10ml swallows (p≤0.026). Pressure variability significantly increased with increasing age (p=0.002). There were no effects of sex on pressure variability (p≥0.15). Pharyngeal swallowing pressure variability differs according pharyngeal region, volume, and age, but not sex. Abnormal swallowing pressure variability may reflect deviations in motor control in persons with swallowing impairment, and results from this study can be used as normative data for future investigations evaluating swallowing pressure generation.
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影响因子：
2.6
作者：
Fei, Tiffany;Polacco, Rebecca Cliffe;Hori, Sarah E.;Molfenter, Sonja M.;Peladeau-Pigeon, Melanie;Tsang, Clemence;Steele, Catriona M.
通讯作者：
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影响因子：
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DOI：
10.1044/2014_jslhr-s-13-0101
发表时间：
2014-06-01
影响因子：
2.6
作者：
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通讯作者：
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影响因子：
29.4
作者：
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通讯作者：
HA, T
影响因子：
2.6
作者：
Hoffman, Matthew R.;Mielens, Jason D.;Ciucci, Michelle R.;Jones, Corinne A.;Jiang, Jack J.;McCulloch, Timothy M.
通讯作者：
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