Water Uptake by Evaporating pMDI Aerosol Prior to Inhalation Affects Both Regional and Total Deposition in the Respiratory System.
Water Uptake by Evaporating pMDI Aerosol Prior to Inhalation Affects Both Regional and Total Deposition in the Respiratory System.
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DOI：
10.3390/pharmaceutics13070941
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发表时间：
2021-06-24
期刊：
影响因子：
5.4
通讯作者：
Reid JP
中科院分区：
文献类型：
--
作者：
Legh-Land V;Haddrell AE;Lewis D;Murnane D;Reid JP
由于肺部药物沉积是气雾剂颗粒大小分布的函数，因此充分了解从生成到吸入之间的颗粒形成和成熟的动力学是至关重要的。本文提出了一种测量挥发性组分和水的蒸发和冷凝通量的方法，该方法使用一种称为单粒子电动肺(SPEL)的新技术来测量PMDI液滴产生后的蒸发和凝结通量。在这样做的过程中，蒸发的气溶胶液滴被证明能够作为水的凝结核。事实上，我们证明了挥发性液滴中挥发性成分的快速蒸发与冷凝所吸收的水的体积直接相关。此外，在蒸发液滴老化过程中，显示出大量的水凝结在模型pMDI配方(氢氟烷烃、乙醇和甘油)的液滴上，显示出从挥发性物种的核心组成向以水为主(在这种情况下仍是非挥发性甘油)的核心组成的戏剧性转变。这产生了一个在吸入时水活度为0.98的液滴。使用国际放射防护委员会(ICRP)的沉积模型，结合吸湿性生长的综合半分析性处理，探讨了这些结果对区域和总的肺部药物沉积的影响。通过这一点，水活度为0.98的水滴在吸入时产生的剂量沉积曲线与吸气点水活度较低的水滴显著不同。
As pulmonary drug deposition is a function of aerosol particle size distribution, it is critical that the dynamics of particle formation and maturation in pMDI sprays in the interim between generation and inhalation are fully understood. This paper presents an approach to measure the evaporative and condensational fluxes of volatile components and water from and to solution pMDI droplets following generation using a novel technique referred to as the Single Particle Electrodynamic Lung (SPEL). In doing so, evaporating aerosol droplets are shown capable of acting as condensation nuclei for water. Indeed, we show that the rapid vaporisation of volatile components from a volatile droplet is directly correlated to the volume of water taken up by condensation. Furthermore, a significant volume of water is shown to condense on droplets of a model pMDI formulation (hydrofluoroalkane (HFA), ethanol and glycerol) during evaporative droplet ageing, displaying a dramatic shift from a core composition of a volatile species to that of predominantly water (non-volatile glycerol remained in this case). This yields a droplet with a water activity of 0.98 at the instance of inhalation. The implications of these results on regional and total pulmonary drug deposition are explored using the International Commission of Radiological Protection (ICRP) deposition model, with an integrated semi-analytical treatment of hygroscopic growth. Through this, droplets with water activity of 0.98 upon inhalation are shown to produce markedly different dose deposition profiles to those with lower water activities at the point of inspiration.
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影响因子：
2.9
作者：
Davies, James F.;Haddrell, Allen E.;Reid, Jonathan P.
通讯作者：
Reid, Jonathan P.
DOI：
10.1073/pnas.1305277110
发表时间：
2013-05-28
影响因子：
11.1
作者：
Davies, James F.;Miles, Rachael E. H.;Reid, Jonathan P.
通讯作者：
Reid, Jonathan P.
影响因子：
5.9
作者：
Crim, C;Holmes, M;Lincourt, W
通讯作者：
Lincourt, W
影响因子：
4.5
作者：
Clegg, SL;Seinfeld, JH;Brimblecombe, P
通讯作者：
Brimblecombe, P
影响因子：
5.8
作者：
Brambilla, G.;Church, T.;Meakin, B.
通讯作者：
Meakin, B.