Parkinson's disease and microRNAs - Lessons from model organisms and human studies.
Parkinson's disease and microRNAs - Lessons from model organisms and human studies.
复制标题
DOI：
10.1016/j.exger.2021.111585
复制
发表时间：
2021-11
影响因子：
3.9
通讯作者：
de Lencastre A
中科院分区：
文献类型：
--
作者：
Evans B;Furlong HA 4th;de Lencastre A
帕金森病(PD)是一种进行性的、与年龄相关的神经退行性疾病，全球估计有1000万人受到影响。帕金森病的特征是含有α突触核蛋白的胞浆内包涵体，称为路易小体，以年龄依赖的方式在多巴胺能神经元中形成，并与特征帕金森病症状的出现有关，如静止性震颤、僵硬、缓慢运动和姿势不稳定。尽管近年来在识别与帕金森病相关的遗传和环境因素方面取得了相当大的进展，但早期诊断和治疗方案仍然严重缺乏。最近，microRNAs(MiRNAs)已成为癌症和神经退行性疾病等多种疾病的新治疗靶点。MiRNAs已被证明在整个门的各种衰老和神经退行性疾病模型中发挥作用。最近，研究已经确定了miRNAs在几种模式生物中的特定作用及其在帕金森病发病和进展中的靶点。在这里，我们讨论miRNAs的演变领域，它们与PD的关联，以及对未来的展望。
Parkinson’s disease (PD) is a progressive, age-associated neurodegenerative disorder that affects an estimated 10 million people worldwide. PD is characterized by proteinaceous, cytoplasmic inclusions containing α-synuclein, called Lewy Bodies, which form in dopaminergic neurons in an age-dependent manner, and are associated with the emergence of characteristic PD symptoms such as resting tremor, rigidity, slow movements and postural instability. Although considerable progress has been made in recent years in identifying genetic and environmental factors that are associated with PD, early diagnosis and therapeutic options remain severely lacking. Recently, microRNAs (miRNAs) have emerged as novel therapeutic targets in various diseases, such as cancer and neurodegenerative diseases. MiRNAs have been shown to play roles in various aging and neurodegenerative disease models across phyla. More recently, studies have identified specific roles for miRNAs and their targets in the pathogenesis and progression of PD in several model organisms. Here, we discuss the evolving field of miRNAs, their association with PD, and the outlook for the future.
登录
查看更多内容
影响因子：
82.9
作者：
Conway, KA;Harper, JD;Lansbury, PT
通讯作者：
Lansbury, PT
影响因子：
14
作者：
Conceicao, Mariana;Mendonca, Liliana;de Almeida, Luis Pereira
通讯作者：
de Almeida, Luis Pereira
microRNA-375 的上调可改善多巴胺能神经元的损伤，通过抑制 SP1 减少帕金森病的氧化应激和炎症
影响因子：
5.2
作者：
Cai, Li-Jun;Tu, Li;Tian, Jin-Yong
通讯作者：
Tian, Jin-Yong
影响因子：
56.9
作者：
Boehm, M;Slack, F
通讯作者：
Slack, F
影响因子：
5.4
作者：
Buratti, Emanuele;De Conti, Laura;Baralle, Francisco
通讯作者：
Baralle, Francisco