Virologic and immunologic response to nucleoside reverse-transcriptase inhibitor therapy among human immunodeficiency virus-infected infants and children.
Virologic and immunologic response to nucleoside reverse-transcriptase inhibitor therapy among human immunodeficiency virus-infected infants and children.
复制标题
人类免疫缺陷病毒感染的婴儿和儿童对核苷逆转录酶抑制剂治疗的病毒学和免疫学反应。
DOI：
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发表时间：
1999
影响因子：
6.4
通讯作者：
J. Englund
中科院分区：
文献类型：
--
作者：
P. Palumbo;C. Raskino;S. Fiscus;S. Pahwa;T. Schutzbank;S. Spector;C. Baker;J. Englund
Plasma human immunodeficiency virus RNA and CD4 lymphocyte response to nucleoside reverse-transcriptase therapy were evaluated in a large, comparative pediatric trial. Both baseline values and changes in the two laboratory markers over time correlated well with clinical outcome and possessed independent predictive value. In comparison of RNA reduction from baseline between the dideoxyinosine (ddI) and zidovudine+ddI therapeutic arms, marginal superiority of the combination arm was not correlated with an observed clinical benefit. Despite the size of this trial and the significantly higher rate of clinical end points in the zidovudine monotherapy group, attempts to establish surrogacy for plasma RNA were difficult. Nevertheless, plasma RNA and CD4 lymphocyte count together possess strong clinical predictive power and are valuable tools for both the clinician and the evaluation of new therapies.
影响因子：
158.5
作者：
Kourtis, AP;Ibegbu, C;Nesheim, S
通讯作者：
Nesheim, S
通过基于聚合酶链反应的检测对人类免疫缺陷病毒感染的婴儿进行病毒测量。
DOI：
10.1016/s0022-3476(95)70357-8
发表时间：
1995
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Palumbo,PE;Kwok,S;Waters,S;Wesley,Y;Lewis,D;McKinney,N;Bardeguez,A;Connor,EM;Oleske,JM
通讯作者：
Oleske,JM
影响因子：
2
作者：
Lin, DY;Fleming, TR;DeGruttola, V
通讯作者：
DeGruttola, V