Optogenetic insights on the relationship between anxiety-related behaviors and social deficits.
Optogenetic insights on the relationship between anxiety-related behaviors and social deficits.
复制标题
对焦虑相关行为与社会缺陷之间关系的光学遗传见解。
DOI：
10.3389/fnbeh.2014.00241
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发表时间：
2014
影响因子：
3
通讯作者：
Tye KM
中科院分区：
文献类型：
--
作者：
Allsop SA;Vander Weele CM;Wichmann R;Tye KM
许多精神疾病的特点是社会领域的缺陷。例如，自闭症谱系障碍和焦虑症之间的共病率很高。然而，社交缺陷和其他精神疾病状态（如焦虑）共同表达的共同神经回路机制仍不清楚。在这里，我们回顾了焦虑相关行为和社会行为的动物模型中神经回路的光遗传学研究，并讨论了杏仁核在介导这些行为方面的重要作用。特别是，我们专注于最近的证据表明，从基底外侧杏仁核（BLA）到腹侧海马（vHPC）的预测调节焦虑相关的行为，也改变社会互动。了解这个回路如何影响社交行为和焦虑，可能会为社交焦虑障碍的发病机制以及自闭症谱系障碍和焦虑障碍患者的患病率提供一个机制性解释。此外，阐明调节社会行为的回路如何也介导其他复杂的情绪状态，将有助于更好地理解社会缺陷在精神疾病中表达的潜在机制。
Many psychiatric illnesses are characterized by deficits in the social domain. For example, there is a high rate of co-morbidity between autism spectrum disorders and anxiety disorders. However, the common neural circuit mechanisms by which social deficits and other psychiatric disease states, such as anxiety, are co-expressed remains unclear. Here, we review optogenetic investigations of neural circuits in animal models of anxiety-related behaviors and social behaviors and discuss the important role of the amygdala in mediating aspects of these behaviors. In particular, we focus on recent evidence that projections from the basolateral amygdala (BLA) to the ventral hippocampus (vHPC) modulate anxiety-related behaviors and also alter social interaction. Understanding how this circuit influences both social behavior and anxiety may provide a mechanistic explanation for the pathogenesis of social anxiety disorder, as well as the prevalence of patients co-diagnosed with autism spectrum disorders and anxiety disorders. Furthermore, elucidating how circuits that modulate social behavior also mediate other complex emotional states will lead to a better understanding of the underlying mechanisms by which social deficits are expressed in psychiatric disease.
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