Chronic gastritis—a pathogenetic approach
Chronic gastritis—a pathogenetic approach
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慢性胃炎——致病途径
DOI：
10.1002/path.1711540203
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
M. Dixon
中科院分区：
文献类型：
--
作者：
J. Wyatt;M. Dixon
直到最近，“非特异性”慢性胃炎还是一个直截了当、没有争议的话题。根据慢性炎症细胞的粘膜浸润深度进行简单的分类通常就足以用于诊断目的。根据急性炎症活动、肠化生和腺体萎缩的存在和严重程度，进一步细化了慢性浅表性胃炎和慢性萎缩性胃炎的分类，但这些特征在常规实践中几乎没有临床意义。以往的病因分类将慢性胃炎分为两种主要类型。一种是自身免疫性胃炎(A型)，可导致恶性贫血，主要累及身体粘膜，与低盐度和血清中抗壁细胞的存在等有关。另一种(B型胃炎)主要见于胃窦，与高盐酸血症和消化性溃疡有关。到目前为止，这一类别被认为是特发性的，尽管在目前的病理学教科书中，外源性刺激物(如热饮和香料)和内源性刺激物(如胆汁返流)都是原因。第三种类型，有点令人困惑地命名为AB，最近被区分为一种在胃窦和体部粘膜都表现为斑片性胃炎的类型，并与胃溃疡、异型增生和胃癌的发生率较高有关。必须强调的是，这些先前描述的致病‘类型’不能在组织学基础上加以区分。
Until recently, the subject of ‘non-specific’ chronic gastritis was straightforward and noncontroversial. A simple classification based on the depth of mucosal infiltration by chronic inflammatory cells has generally sufficed for diagnostic purposes.’ Division into chronic superficial and chronic atrophic gastritis has been further refined to take account of the presence and severity of acute inflammatory activity, intestinal metaplasia, and glandular atrophy,* but these features are of little or no clinical relevance in routine practice. Previous pathogenetic classifications divide chronic gastritis into two main types. One (Type A), the autoimmune gastritis which leads to pernicious anaemia, mainly affects body mucosa and is associated with hypochlorhydria and the presence in the serum of anti-parietal cell an t ib~d ies .~ The other (Type B gastritis) is found predominantly in the antrum and is associated with hyperchlorhydria and peptic ulceration. Thus far, this category has been considered ‘idiopathic’ although irritants both exogenous, such as hot drinks and spices, and endogenous, like bile reflux, are suggested causes in current textbooks of pathology. A third type, somewhat confusingly designated AB, has been distinguished more recently4 as one that exhibits patchy gastritis in both antral and body mucosa and is associated with a higher incidence of gastric ulcer, dysplasia, and gastric cancer. It must be emphasized that these previously described pathogenetic ‘types’ cannot be distinguished on histological grounds.
从雪貂胃粘膜中分离出的弯曲杆菌样生物体。
影响因子：
1
作者：
Fox,JG;Edrise,BM;Cabot,EB;Beaucage,C;Murphy,JC;Prostak,KS
通讯作者：
Prostak,KS
幽门弯曲杆菌降解粘蛋白并破坏胃粘膜完整性。
DOI：
10.1016/s0006-291x(87)80511-9
发表时间：
1987
影响因子：
3.1
作者：
Slomiany,BL;Bilski,J;Sarosiek,J;Murty,VL;Dworkin,B;VanHorn,K;Zielenski,J;Slomiany,A
通讯作者：
Slomiany,A
胃手术后有症状患者的胃组织学：评估胃粘膜损伤选择性模式的模型。
DOI：
10.3109/00365528509103940
发表时间：
1985
期刊：
Scandinavian journal of gastroenterology. Supplement
影响因子：
--
作者：
Weinstein,WM;Buch,KL;Elashoff,J;Reedy,T;Tedesco,FJ;Samloff,IM;Ippoliti,AF
通讯作者：
Ippoliti,AF