Increased Risk of Aging-Related Neurodegenerative Disease after Traumatic Brain Injury.
Increased Risk of Aging-Related Neurodegenerative Disease after Traumatic Brain Injury.
复制标题
创伤性脑损伤后，与衰老相关的神经退行性疾病的风险增加。
DOI：
10.3390/biomedicines11041154
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发表时间：
2023-04-11
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
创伤性脑损伤（TBI）的幸存者经常遭受慢性进展性并发症，包括显着增加的风险，发展与衰老相关的神经退行性疾病。随着神经重症监护的进步增加了TBI幸存者的数量，这个问题的影响和意识正在增长。然而，TBI增加发展与衰老相关的神经退行性疾病的风险的机制尚未完全了解。因此，对患者没有保护性治疗。在这里，我们回顾了目前的文献周围的流行病学和脑损伤和衰老相关的神经退行性疾病之间的潜在机制的关系。除了增加发展成所有形式的痴呆症的风险之外，由TBI加速的最突出的与衰老相关的神经退行性疾病是肌萎缩侧索硬化症（ALS）、额颞叶痴呆症（FTD）、帕金森病（PD）和阿尔茨海默病（AD），其中ALS和FTD是最不完善的。TBI和所有形式的痴呆症之间的机制联系包括氧化应激，蛋白质稳态失调和神经炎症。回顾了与TBI相关的疾病特异性机制，包括ALS和FTD中的TAR DNA结合蛋白43和运动皮质病变; PD中的α-突触核蛋白、多巴胺能细胞死亡和协同毒素暴露; AD中的脑胰岛素抵抗、淀粉样蛋白β病理学和tau病理学。虽然已经确定了令人信服的机制联系，但需要在该领域进行显着扩大的调查，以开发治疗方法，以保护TBI幸存者免受衰老相关神经退行性疾病风险增加的影响。
Traumatic brain injury (TBI) survivors frequently suffer from chronically progressive complications, including significantly increased risk of developing aging-related neurodegenerative disease. As advances in neurocritical care increase the number of TBI survivors, the impact and awareness of this problem are growing. The mechanisms by which TBI increases the risk of developing aging-related neurodegenerative disease, however, are not completely understood. As a result, there are no protective treatments for patients. Here, we review the current literature surrounding the epidemiology and potential mechanistic relationships between brain injury and aging-related neurodegenerative disease. In addition to increasing the risk for developing all forms of dementia, the most prominent aging-related neurodegenerative conditions that are accelerated by TBI are amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Parkinson’s disease (PD), and Alzheimer’s disease (AD), with ALS and FTD being the least well-established. Mechanistic links between TBI and all forms of dementia that are reviewed include oxidative stress, dysregulated proteostasis, and neuroinflammation. Disease-specific mechanistic links with TBI that are reviewed include TAR DNA binding protein 43 and motor cortex lesions in ALS and FTD; alpha-synuclein, dopaminergic cell death, and synergistic toxin exposure in PD; and brain insulin resistance, amyloid beta pathology, and tau pathology in AD. While compelling mechanistic links have been identified, significantly expanded investigation in the field is needed to develop therapies to protect TBI survivors from the increased risk of aging-related neurodegenerative disease.
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影响因子：
64.5
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