What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease.
What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease.
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DOI：
10.1016/j.exer.2013.06.012
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发表时间：
2013-10
影响因子：
3.4
通讯作者：
Russell, Paul
中科院分区：
文献类型：
--
作者：
Morgan, Joshua T.;Murphy, Christopher J.;Russell, Paul
细胞在体内暴露于复杂的信号环境中。生化信号方式，如分泌的蛋白质、特定的细胞外基质结构域和离子通量，无疑构成了一套重要的细胞调节信号。然而，这些信号不是孤立地施加的，而是与周围组织的生物物理线索相一致，例如刚度和地形。在这篇综述中，我们试图强调眼组织的生物物理属性及其对细胞行为的影响。此外，我们还介绍了YAP和TAZ蛋白作为生物物理和生化信号的靶点，以及许多信号通路的重要激动剂和拮抗剂，包括TGFβ和Wnt。我们围绕这种广泛的信号串扰进行讨论，这使得YAP和TAZ能够作为协调分子，能够将生物物理和生化线索整合到广泛的细胞反应中。最后，虽然我们借鉴了各个领域的研究来提供YAP和TAZ的全貌，但我们试图强调与视觉科学的交叉点和已经完成的令人兴奋的工作。
Cells in vivo are exposed to a complex signaling environment. Biochemical signaling modalities, such as secreted proteins, specific extracellular matrix domains and ion fluxes certainly compose an important set of regulatory signals to cells. However, these signals are not exerted in isolation, but rather in concert with biophysical cues of the surrounding tissue, such as stiffness and topography. In this review, we attempt to highlight the biophysical attributes of ocular tissues and their influence on cellular behavior. Additionally, we introduce the proteins YAP and TAZ as targets of biophysical and biochemical signaling and important agonists and antagonists of numerous signaling pathways, including TGFβ and Wnt. We frame the discussion around this extensive signaling crosstalk, which allows YAP and TAZ to act as orchestrating molecules, capable of integrating biophysical and biochemical cues into a broad cellular response. Finally, while we draw on research from various fields to provide a full picture of YAP and TAZ, we attempt to highlight the intersections with vision science and the exciting work that has already been performed.
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DOI：
10.1534/g3.112.004424
发表时间：
2012-11
期刊：
G3 (Bethesda, Md.)
影响因子：
--
作者：
Acharya P;Negre N;Johnston J;Wei Y;White KP;Henry RW;Arnosti DN
通讯作者：
Arnosti DN
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
4.1
作者：
Albon, J;Karwatowski, WSS;Duance, VC
通讯作者：
Duance, VC
影响因子：
4.4
作者：
Davis, Joshua T.;Wen, Qi;Foster, William J.
通讯作者：
Foster, William J.
影响因子：
64.5
作者：
Dong, Jixin;Feldmann, Georg;Pan, Duojia
通讯作者：
Pan, Duojia