Ophthalmic involvement in acquired immunodeficiency syndrome.
Ophthalmic involvement in acquired immunodeficiency syndrome.
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获得性免疫缺陷综合征的眼部受累。
DOI：
10.1016/s0161-6420(84)34201-4
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发表时间：
1984
期刊：
影响因子：
13.7
通讯作者：
R. Steis
中科院分区：
文献类型：
--
作者：
A. Palestine;M. Rodrigues;A. Macher;C. Chan;H. Lane;A. Fauci;H. Masur;D. Longo;C. Reichert;R. Steis
本文对40例获得性免疫缺陷综合征（AIDS）患者进行了眼部异常检查。其中20例死亡，取眼进行培养和组织病理学检查。这些患者有多种机会性感染和肿瘤，这是细胞免疫力严重下降的结果。50%的艾滋病患者和75%的尸检组有可归因于艾滋病的眼部体征。眼部表现主要为巨细胞病毒性视网膜炎（10例）、视网膜棉毛斑（11例）、结膜卡波西肉瘤（2例）和眼神经运动异常（3例）4大类。巨细胞病毒性视网膜炎是视力丧失的重要原因。40只尸检眼睛中有7只在患者因巨细胞病毒性视网膜炎死亡前有手部运动或视力较差。这种坏死性视网膜炎表现为轻微的炎症，并在三到六个月内进展到累及整个视网膜，导致视网膜胶质膜。抗病毒药物治疗无效。认识到艾滋病的眼部症状可能有助于诊断。眼科医生在观察这些眼部表现的进展或消退方面也起着重要作用，并可以协助评估艾滋病患者的治疗。
Forty patients with acquired immunodeficiency syndrome (AIDS) were examined for ocular abnormalities. Twenty of these patients died and the eyes were obtained for culture and histopathologic examination. These patients have multiple opportunistic infections and neoplasms as the result of a severe depression of cellular immunity. Fifty percent of all patients with AIDS and 75% of the autopsy group have ocular signs attributable to AIDS. Ocular findings were confined to four major categories: cytomegalovirus retinitis (10 patients), retinal cotton wool spots (11 patients), conjunctival Kaposi's sarcoma (2 patients) and neuro-ophthalmic motility abnormalities (3 patients). Cytomegalovirus retinitis was a significant cause of visual loss. Seven of 40 autopsy eyes had hand motion or worse visual acuity prior to the patients' death because of CMV retinitis. This necrotic retinitis showed minimal inflammation and progressed to involve the entire retina in three to six months, resulting in a gliotic retinal membrane. Therapy with antiviral agents was not effective. Recognizing the ocular signs of AIDS may facilitate the diagnosis. The ophthalmologist also has a major role in the observation of progression or regression of these ocular manifestations, and can assist in the evaluation of therapy in patients with AIDS.
影响因子：
13.7
作者：
G. Holland;G. Holland;J. Pepose;T. H. Pettit;T. H. Pettit;M. Gottlieb;R. Yee;R. Yee;R. Foos;R. Foos
通讯作者：
G. Holland;G. Holland;J. Pepose;T. H. Pettit;T. H. Pettit;M. Gottlieb;R. Yee;R. Yee;R. Foos;R. Foos