Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents.
Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents.
复制标题
表面健康的男性青少年精神分裂症的行为和智力标志。
DOI：
10.1176/ajp.156.9.1328
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Mordehai Mark
中科院分区：
文献类型：
--
作者：
M. Davidson;A. Reichenberg;J. Rabinowitz;M. Weiser;Z. Kaplan;Mordehai Mark
目标
表面上健康的青少年通常会出现微妙的行为和智力异常，但后来会患上精神分裂症。作者调查了这些异常是否可以在首次精神病表现之前预测精神分裂症的易感性。
方法
该研究包括将以色列征兵委员会登记处与国家精神病住院病例登记处联系起来。选秀委员会测试衡量智力、社会功能、组织能力、体育活动兴趣和个人自主性。将患者（N = 509）与非患者（即未出现在国家精神病学登记处的青少年（N = 9,215））进行比较，并按年龄、性别和测试时就读的学校与患者进行匹配。
结果
后来因精神分裂症住院的健康男性青少年在所有指标上的测试分数均显着低于未向国家精神病学登记处报告的青少年。精神分裂症最有力的预测因素是社会功能、组织能力和智力功能的缺陷。当患者与匹配的非患者进行比较时，预测模型的敏感性为 75%，特异性为 100%，阳性预测值为 72%，总体正确分类率为 87.5%。该模型应用于以色列征兵委员会登记处后，敏感性为 74.7%，验证特异性为 99.7%，阳性预测值为 42.7%。
结论
这项研究表明，简单的评估工具可以预测健康男性青少年的精神分裂症倾向。该模型的预测能力不会随着测试和首次住院之间经过的时间而变化。这表明该模型识别出表面上健康的个体，这些个体稍后会表现出疾病，并且不会成为精神病的前驱体。易于应用的工具可以早期识别精神分裂症或易患精神分裂症的脆弱性，可以实现早期干预。
OBJECTIVE
Subtle behavioral and intellectual abnormalities are often present in apparently healthy adolescents who later develop schizophrenia. The authors investigated whether these abnormalities can predict vulnerability for schizophrenia before the first psychotic manifestation.
METHOD
The study consisted of linking the Israeli Draft Board Registry with the National Psychiatric Hospitalization Case Registry. The draft board tests measure intelligence, social functioning, organizational ability, interest in physical activity, and individual autonomy. Patients (N = 509) were compared to nonpatients, i.e., adolescents not appearing in the National Psychiatric Registry (N = 9,215), matched to patients by age, gender, and school attended at time of testing.
RESULTS
Healthy male adolescents who were later hospitalized for schizophrenia had significantly lower test scores on all measures than adolescents not reported to the National Psychiatric Registry. The strongest predictors for schizophrenia were deficits in social functioning, organizational ability, and intellectual functioning. When patients were compared to matched nonpatients, the prediction model had a 75% sensitivity, a 100% specificity, a positive predictive value of 72%, and an overall rate of correct classification of 87.5%. Applied to the Israeli Draft Board Registry, the model yielded a sensitivity of 74.7%, a validated specificity of 99.7%, and a positive predictive value of 42.7%.
CONCLUSIONS
This study demonstrated that simple assessment tools can predict predisposition to schizophrenia in healthy male adolescents. The model's predictive ability does not change as a function of the time elapsed between testing and first hospitalization. This suggests that the model identifies apparently healthy individuals who will manifest the disease later who are not prodromal to psychosis. Easily applied tools allowing early identification of schizophrenia or vulnerability to it may enable early intervention.
影响因子：
--
作者：
E. Susser;R. Neugebauer;H. Hoek;A. Brown;S. Lin;D. Labovitz;J. Gorman
通讯作者：
E. Susser;R. Neugebauer;H. Hoek;A. Brown;S. Lin;D. Labovitz;J. Gorman
DOI：
10.1176/ajp.154.4.475
发表时间：
1997
期刊：
The American journal of psychiatry
影响因子：
--
作者：
H. Meltzer;H. Meltzer;J. Rabinowitz;M. Lee;P. Cola;Rakesh Ranjan;R. Findling;Paul Thompson
通讯作者：
H. Meltzer;H. Meltzer;J. Rabinowitz;M. Lee;P. Cola;Rakesh Ranjan;R. Findling;Paul Thompson
DOI：
10.1176/ajp.149.9.1183
发表时间：
1992-09
期刊：
The American journal of psychiatry
影响因子：
--
作者：
A. Loebel;J. Lieberman;J. Alvir;D. Mayerhoff;S. Geisler;Szymański
通讯作者：
A. Loebel;J. Lieberman;J. Alvir;D. Mayerhoff;S. Geisler;Szymański