Isolates of Liao ning virus from wild-caught mosquitoes in the Xinjiang province of China in 2005.
Isolates of Liao ning virus from wild-caught mosquitoes in the Xinjiang province of China in 2005.
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DOI：
10.1371/journal.pone.0037732
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Attoui H
中科院分区：
文献类型：
--
作者：
Lv X;Mohd Jaafar F;Sun X;Belhouchet M;Fu S;Zhang S;Tong SX;Lv Z;Mertens PP;Liang G;Attoui H
辽宁病毒（LNV）与班纳病毒有关，班纳病毒是一种已知存在于东南亚的人类病原体。这两种病毒都属于呼肠孤病毒科的Seadornavirus属。LNV在实验感染的小鼠中引起致死性出血。2005年，从中国西北部新疆省不同地点收集的蚊子中分离出27株LNV。这些蚊子是在有发热表现的人类患者的住所或以绵羊为主要牲畜物种的动物谷仓中捕获的。LNV被隔离的地区受到季节性脑炎的影响，但没有日本脑炎（JE）。对多个LNV分离株的基因组片段10（Seg-10）（编码细胞附着和病毒型决定蛋白VP 10）和Seg-12（编码非结构蛋白VP 12）进行测序。系统发育分析表明，一个不太同质的Seg-10基因池，相比，第12段。然而，所有这些分离株似乎都属于LNV 1型。这些数据表明LNV传入新疆的时间相对较晚，LNV Seg-10和Seg-12的替换率分别为2.29×10−4和1.57×10−4替换/nt/年。这些取代率与其他dsRNA病毒的估计值相似。我们的数据表明，LNV的历史特点是缺乏人口波动。然而，1980年代末至1990年代初，第10区和第12区的数据表明，LNV人口有所下降。数据还表明，从Seg-12天际线图推断，在20世纪90年代末开始扩张。
Liao ning virus (LNV) is related to Banna virus, a known human-pathogen present in south-east Asia. Both viruses belong to the genus Seadornavirus, family Reoviridae. LNV causes lethal haemorrhage in experimentally infected mice. Twenty seven isolates of LNV were made from mosquitoes collected in different locations within the Xinjiang province of north-western China during 2005. These mosquitoes were caught in the accommodation of human patients with febrile manifestations, or in animal barns where sheep represent the main livestock species. The regions where LNV was isolated are affected by seasonal encephalitis, but are free of Japanese encephalitis (JE). Genome segment 10 (Seg-10) (encoding cell-attachment and serotype-determining protein VP10) and Seg-12 (encoding non-structural protein VP12) were sequenced for multiple LNV isolates. Phylogenetic analyses showed a less homogenous Seg-10 gene pool, as compared to segment 12. However, all of these isolates appear to belong to LNV type-1. These data suggest a relatively recent introduction of LNV into Xinjiang province, with substitution rates for LNV Seg-10 and Seg-12, respectively, of 2.29×10−4 and 1.57×10−4 substitutions/nt/year. These substitution rates are similar to those estimated for other dsRNA viruses. Our data indicate that the history of LNV is characterized by a lack of demographic fluctuations. However, a decline in the LNV population in the late 1980s - early 1990s, was indicated by data for both Seg-10 and Seg-12. Data also suggest a beginning of an expansion in the late 1990s as inferred from Seg-12 skyline plot.
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影响因子：
4.9
作者：
Clement, M;Posada, D;Crandall, KA
通讯作者：
Crandall, KA
影响因子：
3.1
作者：
Billoir, F;Attoui, H;de Lamballerie, X
通讯作者：
de Lamballerie, X
影响因子：
2.7
作者：
Attoui, H;Jaafar, FM;de Lamballerie, X
通讯作者：
de Lamballerie, X
影响因子：
9.8
作者：
Drummond AJ;Ho SY;Phillips MJ;Rambaut A
通讯作者：
Rambaut A
影响因子：
5.7
作者：
Jaafar, FM;Attoui, H;De Lamballerie, X
通讯作者：
De Lamballerie, X