An exploratory approach demonstrating immune skewing and a loss of coordination among cytokines in plasma and saliva of Veterans with combat-related PTSD.
An exploratory approach demonstrating immune skewing and a loss of coordination among cytokines in plasma and saliva of Veterans with combat-related PTSD.
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DOI：
10.1016/j.humimm.2016.05.018
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发表时间：
2016-08
期刊：
影响因子：
2.7
通讯作者：
Young MRI
中科院分区：
文献类型：
--
作者：
Wang Z;Mandel H;Levingston CA;Young MRI
研究表明，创伤后应激障碍与炎症状态有关，尽管很少有研究研究在创伤后应激障碍中刺激性和抑制性免疫介质之间的平衡。采用探索性方法评估与创伤后应激障碍相关的Th1刺激性、炎性和抑制性介质之间的免疫失衡。这种方法关注的是受到严格控制且相对同质的退伍军人群体，他们在阿富汗和伊拉克战争中的战斗暴露水平相似，但一些检测呈阴性，另一些检测为创伤后应激障碍呈阳性。虽然样本量很小(6名对照组和7名PTSD患者)，而且这项研究的局限性，但结果显示，在患有PTSD的退伍军人中，有利于Th1和炎症状态的免疫细胞因子显著失衡，抑制性细胞因子水平降低。与他们的血浆相比，创伤后应激障碍受试者的唾液中的这一点尤其突出。
Studies have suggested PTSD to be associated with an inflammatory state, although few studies have examined the balances between stimulatory and inhibitory immune mediators in PTSD. An exploratory approach was taken to assess the immune imbalances between Th1 stimulatory, inflammatory and inhibitory mediators associated with PTSD. This approach focused on a tightly-controlled and relatively homogeneous population of Veterans, all with similar levels of combat exposure in the Afghanistan and Iraq wars, but some testing negative and others testing positive for PTSD. Although the sample size was small (6 controls and 7 with PTSD) and a limitation of this study, the results showed significant imbalances in immune cytokines favoring a Th1 and inflammatory state, with reduced levels of inhibitory cytokines in Veterans with PTSD. This was particularly prominent in the saliva of PTSD subjects compared to in their plasma.
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