Revisiting the Teleost Thymus: Current Knowledge and Future Perspectives.
Revisiting the Teleost Thymus: Current Knowledge and Future Perspectives.
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DOI：
10.3390/biology10010008
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发表时间：
2020-12-25
期刊：
影响因子：
4.2
通讯作者：
Imarai M
中科院分区：
文献类型：
--
作者：
Barraza F;Montero R;Wong-Benito V;Valenzuela H;Godoy-Guzmán C;Guzmán F;Köllner B;Wang T;Secombes CJ;Maisey K;Imarai M
胸腺是产生T淋巴细胞的免疫器官，T淋巴细胞在遇到病原体或接种疫苗后对产生免疫力至关重要。本文综述了硬骨鱼类胸腺的定位、组织学研究、细胞组成和功能。我们还描述了季节变化，光周期，水温波动和激素如何影响鱼类胸腺发育。总的来说，这些信息有助于确定未来的研究需要了解鱼类胸腺功能和免疫系统的进化起源。由于鱼类接触病原体，特别是在水产养殖条件下，有关鱼类胸腺和T淋巴细胞的知识也有助于改善鱼类养殖方案，考虑到内在和环境条件，有助于实现最佳的疫苗抗病反应。脊椎动物的胸腺在产生具有功能的T淋巴细胞方面起着关键作用。在系统发育上，胸腺在有颌软骨鱼的进化过程中出现较早，通常是一个位于鳃盖背连合皮下的双侧器官。本文综述了硬骨鱼类胸腺的定位、组织学研究、细胞组成和功能等方面的研究进展。此外，我们还考虑了影响胸腺发育的环境因素，如季节变化、光周期、水温波动和激素。对胸腺细胞分布和功能的进一步分析将有助于我们了解鱼类发育功能性T细胞的关键阶段是如何发生的，以及胸腺动力学如何受到光周期等外部因素的调节。总体而言，这里提供的信息有助于确定知识差距和更好地了解鱼类胸腺的免疫生物学所需的未来步骤。
The thymus is the immune organ producing T lymphocytes that are essential to create immunity after encountering pathogens or vaccination. This review summarizes the thymus localization and histological studies, cell composition, and function in teleost fishes. We also describe how seasonal changes, photoperiod, water temperature fluctuations, and hormones can affect thymus development in fish species. Overall, the information helps identify future studies needed to understand thymus function in fish species and the immune system’s evolutionary origins. Since fish are exposed to pathogens, especially under aquaculture conditions, knowledge about the fish thymus and T lymphocyte can also help improve fish farming protocols, considering intrinsic and environmental conditions that can contribute to achieving the best vaccine responsiveness for disease resistance. The thymus in vertebrates plays a critical role in producing functionally competent T-lymphocytes. Phylogenetically, the thymus emerges early during evolution in jawed cartilaginous fish, and it is usually a bilateral organ placed subcutaneously at the dorsal commissure of the operculum. In this review, we summarize the current understanding of the thymus localization, histology studies, cell composition, and function in teleost fishes. Furthermore, we consider environmental factors that affect thymus development, such as seasonal changes, photoperiod, water temperature fluctuations and hormones. Further analysis of the thymus cell distribution and function will help us understand how key stages for developing functional T cells occur in fish, and how thymus dynamics can be modulated by external factors like photoperiod. Overall, the information presented here helps identify the knowledge gaps and future steps needed for a better understanding of the immunobiology of fish thymus.
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影响因子：
7.3
作者：
Aghaallaei N;Bajoghli B
通讯作者：
Bajoghli B
影响因子：
4.2
作者：
Abram QH;Dixon B;Katzenback BA
通讯作者：
Katzenback BA
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作者：
Castro, Rosario;Bromage, Erin;Tafalla, Carolina
通讯作者：
Tafalla, Carolina
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作者：
Bajoghli, Baubak;Kuri, Paola;Leptin, Maria
通讯作者：
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影响因子：
2.9
作者：
CHILMONCZYK, S
通讯作者：
CHILMONCZYK, S