MIER3 suppresses colorectal cancer progression by down-regulating Sp1, inhibiting epithelial-mesenchymal transition.
MIER3 suppresses colorectal cancer progression by down-regulating Sp1, inhibiting epithelial-mesenchymal transition.
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MIER3 通过下调 Sp1 抑制上皮间质转化来抑制结直肠癌进展
DOI：
10.1038/s41598-017-11374-y
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发表时间：
2017-09-08
影响因子：
4.6
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Peng M;Hu Y;Song W;Duan S;Xu Q;Ding Y;Geng J;Zhou J
中胚层诱导早期反应1，家族成员3（MIER3）最近被确定为潜在的癌症易感基因。然而，MIER3在结直肠癌（CRC）进展中的表达模式和作用尚未得到很好的表征。在这里，我们报道了MIER3在人类原发性结直肠癌中显著降低，并与CRC转移和预后不良相关。MIER3表达上调可显著抑制大肠癌细胞的增殖、迁移和侵袭，抑制体内肿瘤的生长和转移。相反，MIER3的下调可促进CRC细胞的侵袭行为。此外，我们的研究表明，MIER3抑制细胞增殖和侵袭部分通过减少Sp1和随后的上皮间质转化（EMT）的抑制。总之，我们的数据表明，MIER3在结直肠癌进展中起着潜在的肿瘤抑制作用，可能是这种疾病的潜在有价值的临床预后标志物。
Mesoderm induction early response 1, family member 3 (MIER3) has recently been identified as a potential cancer susceptibility gene. However, the expression pattern and the role of MIER3 in the progression of colorectal cancer (CRC) have not yet been well characterized. Here, we reported that MIER3 was significantly reduced in human primary colorectal cancer and was associated with CRC metastasis and poor prognosis. Moreover, the up-regulation of MIER3 expression significantly inhibited CRC cell proliferation, migration and invasionin vitroand repressed tumor growth and metastasisin vivo. In contrast, down-regulation of MIER3 could promote the aggressive behaviors of CRC cells. Furthermore, our study showed that MIER3 inhibited cell proliferation and invasion partially via reduction of Sp1 and subsequent suppression of epithelial-mesenchymal transition (EMT). In conclusion, our data suggested that MIER3 plays a potential tumor suppressor role in CRC progression and may be a potentially valuable clinical prognostic marker of this disease.
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影响因子：
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作者：
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影响因子：
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