Eurasian house mouse (Mus musculus L.) differentiation at microsatellite loci identifies the Iranian plateau as a phylogeographic hotspot.
Eurasian house mouse (Mus musculus L.) differentiation at microsatellite loci identifies the Iranian plateau as a phylogeographic hotspot.
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DOI：
10.1186/s12862-015-0306-4
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发表时间：
2015-02-25
影响因子：
3.4
通讯作者：
Bonhomme F
中科院分区：
文献类型：
--
作者：
Hardouin EA;Orth A;Teschke M;Darvish J;Tautz D;Bonhomme F
家鼠(Mus Musculus L.)是遗传和生物医学研究的标志性物种，对其系统地理的了解只有一部分，主要是因为对其在欧洲、亚洲和美洲最边缘的种群存在抽样偏见。此外，目前的系统地理假说大多源于对线粒体谱系的研究。在这篇文章中，我们通过对47个种群样本中963个个体的核标记(19个微卫星座位)的全面调查来补充mtDNA研究，重点是假定的中东物种扩散中心。基于对应分析、距离和等位基因共享树，我们发现种群的地理起源和遗传组成之间有很好的一致性。因此，我们确认了三个描述最好的外周亚种--肌肉分枝杆菌、家养分枝杆菌和卡氏分枝杆菌的明显区别。在伊朗种群中发现了大量的多样性，到目前为止，伊朗种群的分类地位尚不清楚。除了与肌肉分枝杆菌和家养分枝杆菌有明确关联的样本外，我们还在伊朗中部和东南部发现了两个基因群，它们彼此之间的差异与来自东南亚的卡氏分枝杆菌一样不同。这些群体之前也被发现拥有不同的线粒体单倍型。我们认为，伊朗高原是另外两个分类单位的所在地，这些单位显示了与其长期公认的邻国之间复杂的主要和次要关系。在一个有限的地理区域内，这一中心地区是已知老鼠血统多样性最高的地区，指定它为研究该物种物种形成和多样化机制的重点地点。本文的在线版本(doi：10.1186/s12862-015-0306-4)包含补充材料，授权用户可以使用。
The phylogeography of the house mouse (Mus musculus L.), an emblematic species for genetic and biomedical studies, is only partly understood, essentially because of a sampling bias towards its most peripheral populations in Europe, Asia and the Americas. Moreover, the present-day phylogeographic hypotheses stem mostly from the study of mitochondrial lineages. In this article, we complement the mtDNA studies with a comprehensive survey of nuclear markers (19 microsatellite loci) typed in 963 individuals from 47 population samples, with an emphasis on the putative Middle-Eastern centre of dispersal of the species. Based on correspondence analysis, distance and allele-sharing trees, we find a good coherence between geographical origin and genetic make-up of the populations. We thus confirm the clear distinction of the three best described peripheral subspecies, M. m. musculus, M. m. domesticus and M. m. castaneus. A large diversity was found in the Iranian populations, which have had an unclear taxonomic status to date. In addition to samples with clear affiliation to M. m. musculus and M. m. domesticus, we find two genetic groups in Central and South East Iran, which are as distinct from each other as they are from the south-east Asian M. m. castaneus. These groups were previously also found to harbor distinct mitochondrial haplotypes. We propose that the Iranian plateau is home to two more taxonomic units displaying complex primary and secondary relationships with their long recognized neighbours. This central region emerges as the area with the highest known diversity of mouse lineages within a restricted geographical area, designating it as the focal place to study the mechanisms of speciation and diversification of this species. The online version of this article (doi:10.1186/s12862-015-0306-4) contains supplementary material, which is available to authorized users.
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影响因子：
9.8
作者：
Church DM;Goodstadt L;Hillier LW;Zody MC;Goldstein S;She X;Bult CJ;Agarwala R;Cherry JL;DiCuccio M;Hlavina W;Kapustin Y;Meric P;Maglott D;Birtle Z;Marques AC;Graves T;Zhou S;Teague B;Potamousis K;Churas C;Place M;Herschleb J;Runnheim R;Forrest D;Amos-Landgraf J;Schwartz DC;Cheng Z;Lindblad-Toh K;Eichler EE;Ponting CP;Mouse Genome Sequencing Consortium
通讯作者：
Mouse Genome Sequencing Consortium
影响因子：
3.7
作者：
Gabriel, Sofia I.;Stevens, Mark I.;Searle, Jeremy B.
通讯作者：
Searle, Jeremy B.
影响因子：
2
作者：
Orth, A;Belkhir, K;Bonhomme, F
通讯作者：
Bonhomme, F
影响因子：
2.1
作者：
Din, W;Anand, R;Bonhomme, F
通讯作者：
Bonhomme, F
影响因子：
4.9
作者：
Nunome, Mitsuo;Ishimori, Chikako;Suzuki, Hitoshi
通讯作者：
Suzuki, Hitoshi