Early Rehabilitation Exercise after Stroke Improves Neurological Recovery through Enhancing Angiogenesis in Patients and Cerebral Ischemia Rat Model.
Early Rehabilitation Exercise after Stroke Improves Neurological Recovery through Enhancing Angiogenesis in Patients and Cerebral Ischemia Rat Model.
复制标题
中风后早期康复运动通过增强患者和脑缺血大鼠模型的血管生成来改善神经功能恢复
DOI：
10.3390/ijms231810508
复制
发表时间：
2022-09-10
影响因子：
5.6
通讯作者：
Wang, Lai
中科院分区：
文献类型：
--
作者：
Geng, Huixia;Li, Min;Tang, Jing;Lv, Qing;Li, Ruiling;Wang, Lai
在脑血管疾病中，缺血性中风是导致死亡和残疾的主要原因。组织型纤溶酶原激活剂溶栓治疗是临床治疗的首选，但由于患者自身特点要求较高，其应用受到限制。因此，卒中后神经康复策略的选择是促进患者神经功能恢复的重要防治策略。结果表明，康复训练能显著改善患者的神经功能(6.47±1.589比3.21±1.069和0.76±0.852)、运动能力(15.68±5.95比162.32±9.286和91.18±7.377)、日常生活能力(23.37±5.196比66.95±4.707和6.55±2.873)。1个月和3个月患者的生活质量分别为114.39±7.772、168.61±6.323和215.95±10.977，其促进康复的能力明显优于卒中后72 h进行康复锻炼的患者(p<；0.001)。动物实验表明，大鼠大脑中动脉闭塞再灌流2 4h后，平板运动可抑制神经细胞凋亡，缩小脑梗塞体积，3、5d分别为(15.0 4±1.0 7)%、(8.33±1.53)%、(7.2 2±1.478)、(4.44±0.784)、(4.44±0.784)、(6.0 0±0.767)d。机制研究表明，跑台运动通过上调血管内皮生长因子和层粘连蛋白的表达，增加微血管密度，调节血管生成，促进神经功能的恢复。本研究表明，卒中后24小时的康复锻炼有利于促进患者神经功能的恢复，为卒中患者的临床康复提供了科学的参考。
Among cerebrovascular diseases, ischemic stroke is a leading cause of mortality and disability. Thrombolytic therapy with tissue plasminogen activator is the first choice for clinical treatment, but its use is limited due to the high requirements of patient characteristics. Therefore, the choice of neurological rehabilitation strategies after stroke is an important prevention and treatment strategy to promote the recovery of neurological function in patients. This study shows that rehabilitation exercise 24 h after stroke can significantly improve the neurological function (6.47 ± 1.589 vs. 3.21 ± 1.069 and 0.76 ± 0.852), exercise ability (15.68 ± 5.95 vs. 162.32 ± 9.286 and 91.18 ± 7.377), daily living ability (23.37 ± 5.196 vs. 66.95 ± 4.707 and 6.55 ± 2.873), and quality of life (114.39 ± 7.772 vs. 168.61 ± 6.323 and 215.95 ± 10.977) of patients after 1 month and 3 months, and its ability to promote rehabilitation is better than that of rehabilitation exercise administered to patients 72 h after stroke (p < 0.001). Animal experiments show that treadmill exercise 24 h after middle cerebral artery occlusion and reperfusion can inhibit neuronal apoptosis, reduce the volume of cerebral infarction on the third (15.04 ± 1.07% vs. 30.67 ± 3.06%) and fifth (8.33 ± 1.53% vs. 30.67 ± 3.06%) days, and promote the recovery of neurological function on the third (7.22 ± 1.478 vs. 8.28 ± 1.018) and fifth (4.44 ± 0.784 vs. 6.00 ± 0.767) days. Mechanistic studies have shown that treadmill exercise increases the density of microvessels, regulates angiogenesis, and promotes the recovery of nerve function by upregulating the expression of vascular endothelial growth factor and laminin. This study shows that rehabilitation exercise 24 h after stroke is conducive to promoting the recovery of patients’ neurological function, and provides a scientific reference for the clinical rehabilitation of stroke patients.
登录
查看更多内容
影响因子：
5.8
作者：
Coleman ER;Moudgal R;Lang K;Hyacinth HI;Awosika OO;Kissela BM;Feng W
通讯作者：
Feng W
颅内动脉粥样硬化性狭窄中维持脑灌注：顺行残余血流和软脑膜侧支血流的作用。
影响因子：
6.3
作者：
Lan, Linfang;Leng, Xinyi;Leung, Thomas W.
通讯作者：
Leung, Thomas W.
DOI：
10.1007/978-981-10-4304-8_9
发表时间：
2017-01-01
期刊：
EXERCISE FOR CARDIOVASCULAR DISEASE PREVENTION AND TREATMENT: FROM MOLECULAR TO CLINICAL, PT 2
影响因子：
--
作者：
Han, Peipei;Zhang, Wen;Guo, Qi
通讯作者：
Guo, Qi
影响因子：
168.9
作者：
Bernhardt, Julie;Langhorne, Peter;Donnan, Geoffrey
通讯作者：
Donnan, Geoffrey
影响因子：
4.4
作者：
Geng, Hui-Xia;Li, Rui-Ping;Deng, Jie-Xin
通讯作者：
Deng, Jie-Xin