Analgesic effects of alcohol in adults with chronic jaw pain.
Analgesic effects of alcohol in adults with chronic jaw pain.
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DOI：
10.1111/acer.14883
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发表时间：
2022-08
期刊：
影响因子：
--
通讯作者：
Boissoneault, Jeff
中科院分区：
文献类型：
--
作者：
Vitus, Darya;Williams, Michelle K.;Rizk, Mehdi;Neubert, John K.;Robinson, Michael;Boissoneault, Jeff
虽然最近的文献提供了有希望的支持酒精的镇痛性能，酒精镇痛作为慢性疼痛状态的功能的潜在差异还没有得到很好的理解。因此，本研究探讨了慢性疼痛状态作为酒精镇痛的潜在调节剂，并区分了疼痛体验和敏感性的多个方面：疼痛阈值，疼痛强度，疼痛不愉快和感知缓解。有（N=19）和没有（N=29）慢性下颌疼痛的社交饮酒者以平衡顺序完成了两个测试阶段：酒精（目标BrAC= 0.08 g/dl）和安慰剂。在每一个，压力痛觉测量进行插入咬肌。通过检查饮料条件、压力水平（4-、5-或6-lbf）、和慢性颌痛状态（慢性疼痛与无痛对照）的定量感觉测试（QST）测量和伤害性刺激后的疼痛缓解评级。分析表明，在酒精条件下，疼痛阈值和疼痛缓解显着增加，以及疼痛不愉快和疼痛强度减少。慢性疼痛参与者，与对照组相比，表现出较低的疼痛阈值，更大的疼痛强度和疼痛不愉快的评级。研究结果为酒精的镇痛和缓解疼痛作用提供了实验证据，并表明这些作用在慢性疼痛状态下没有显着差异。结果表明，无论慢性疼痛状态如何，通过饮酒自我抑制疼痛的个体可能处于从事危险饮酒模式和经历不良酒精相关后果的高风险中。
Though recent literature provides promising support for the analgesic properties of alcohol, potential differences in alcohol analgesia as a function of chronic pain status are not well understood. Thus, this study examined chronic pain status as a potential moderator of alcohol analgesia and distinguished between multiple aspects of pain experience and sensitivity: pain threshold, pain intensity, pain unpleasantness, and perceived relief. Social drinkers with (N=19) and without (N=29) chronic jaw pain completed two testing sessions in a counterbalanced order: alcohol (target BrAC=.08 g/dl) and placebo. In each, pressure algometry was performed at the insertion of the masseter. Alcohol analgesia was assessed by examining main and interactive effects of beverage condition, pressure level (4-, 5-, or 6-lbf.), and chronic jaw pain status (chronic pain vs. pain-free control) on quantitative sensory testing (QST) measures and pain relief ratings following noxious stimuli. Analyses indicated significant increases in pain threshold and pain relief, as well as reductions in pain unpleasantness and pain intensity, under the alcohol condition. Chronic pain participants, compared to controls, demonstrated lower pain thresholds, and greater pain intensity and pain unpleasantness ratings. Findings provide experimental evidence of alcohol’s analgesic and pain-relieving effects and suggest these effects do not significantly differ by chronic pain status. Results suggest that individuals, regardless of chronic pain status, who self-medicate pain via alcohol consumption may be at high risk for engaging in hazardous drinking patterns and experiencing adverse alcohol-related consequences.
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DOI：
10.1146/annurev-clinpsy-050718-095440
发表时间：
2019-01-01
期刊：
ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 15
影响因子：
--
作者：
Ditre, Joseph W.;Zale, Emily L.;LaRowe, Lisa R.
通讯作者：
LaRowe, Lisa R.
影响因子：
14.5
作者：
Hashmi, Javeria A.;Baliki, Marwan N.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania
影响因子：
3.8
作者：
Ferguson, Erin;Zale, Emily;Boissoneault, Jeff
通讯作者：
Boissoneault, Jeff
影响因子：
3.7
作者：
Forbes EE;Rodriguez EE;Musselman S;Narendran R
通讯作者：
Narendran R
影响因子：
4
作者：
Gaskin, Darrell J.;Richard, Patrick
通讯作者：
Richard, Patrick