Prefrontal response and frontostriatal functional connectivity to monetary reward in abstinent alcohol-dependent young adults.
Prefrontal response and frontostriatal functional connectivity to monetary reward in abstinent alcohol-dependent young adults.
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DOI：
10.1371/journal.pone.0094640
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Narendran R
中科院分区：
文献类型：
--
作者：
Forbes EE;Rodriguez EE;Musselman S;Narendran R
虽然在成瘾模型中广泛提出了神经奖励回路功能的改变，但最近的概念观点强调了前额叶区域反应中断的作用。眶额皮层、内侧前额叶皮层和背外侧前额叶皮层等区域的变化被认为有助于成瘾的核心强迫性、冲动性和执行功能的改变。此外，很少有研究检查这些区域在年轻成年期的功能，当暴露的慢性程度低于酒精依赖成年人的典型样本。为了解决这些问题，我们研究了24名酒精依赖成年人和24名精神健康成年人在金钱奖励期间的神经反应和功能连接。酒精依赖的成年人表现出较少的反应，收到金钱奖励的一组前额叶皮层，包括内侧前额叶皮层，外侧眶额皮层，背外侧前额叶皮层。酒精依赖的成年人也表现出更大的负相关性，在每个这些区域的功能，并在延髓核。在酒精依赖组中，那些有酒精依赖家族史的人表现出较低的mPFC反应，而那些经常饮酒的人表现出mPFC和延髓核之间更大的负功能连接。这些发现表明，酒精依赖与前额叶皮质区的参与较少有关，表明腹侧纹状体反应的调节较弱或中断。这种前额叶反应和额纹状体连接的模式对成瘾的典型行为模式有影响。此外，脑行为研究结果表明，在酒精依赖的额纹状体电路中断的潜在机制，包括家庭责任的酒精使用问题和更频繁地使用酒精。总之，这些研究结果建立在成瘾中奖赏回路功能的现有文献基础上，并提出了酒精依赖中功能中断的机制。
Although altered function in neural reward circuitry is widely proposed in models of addiction, more recent conceptual views have emphasized the role of disrupted response in prefrontal regions. Changes in regions such as the orbitofrontal cortex, medial prefrontal cortex, and dorsolateral prefrontal cortex are postulated to contribute to the compulsivity, impulsivity, and altered executive function that are central to addiction. In addition, few studies have examined function in these regions during young adulthood, when exposure is less chronic than in typical samples of alcohol-dependent adults. To address these issues, we examined neural response and functional connectivity during monetary reward in 24 adults with alcohol dependence and 24 psychiatrically healthy adults. Adults with alcohol dependence exhibited less response to the receipt of monetary reward in a set of prefrontal regions including the medial prefrontal cortex, lateral orbitofrontal cortex, and dorsolateral prefrontal cortex. Adults with alcohol dependence also exhibited greater negative correlation between function in each of these regions and that in the nucleus accumbens. Within the alcohol-dependent group, those with family history of alcohol dependence exhibited lower mPFC response, and those with more frequent drinking exhibited greater negative functional connectivity between the mPFC and the nucleus accumbens. These findings indicate that alcohol dependence is associated with less engagement of prefrontal cortical regions, suggesting weak or disrupted regulation of ventral striatal response. This pattern of prefrontal response and frontostriatal connectivity has consequences for the behavior patterns typical of addiction. Furthermore, brain-behavior findings indicate that the potential mechanisms of disruption in frontostriatal circuitry in alcohol dependence include family liability to alcohol use problems and more frequent use of alcohol. In all, these findings build on the extant literature on reward-circuit function in addiction and suggest mechanisms for disrupted function in alcohol dependence.
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影响因子：
56.9
作者：
Hare, Todd A.;Camerer, Colin F.;Rangel, Antonio
通讯作者：
Rangel, Antonio
影响因子：
3.7
作者：
Dixon ML;Christoff K
通讯作者：
Christoff K
影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
影响因子：
5.3
作者：
Bjork, JM;Knutson, B;Hommer, DW
通讯作者：
Hommer, DW
DOI：
10.1073/pnas.0802127105
发表时间：
2008-09-30
影响因子：
11.1
作者：
Dreher, Jean-Claude;Meyer-Lindenberg, Andreas;Berman, Karen Faith
通讯作者：
Berman, Karen Faith