Vertebrate intestinal endoderm development.

Vertebrate intestinal endoderm development.
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DOI:
10.1002/dvdy.22540
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发表时间:
2011-03
期刊:
Developmental dynamics : an official publication of the American Association of Anatomists
影响因子:
--
通讯作者:
Shroyer NF
Shroyer NF
中科院分区:
其他
文献类型:
--
作者:
Spence JR;Lauf R;Shroyer NF

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内胚层形成食道、胃、肠以及相关器官的内膜。为了产生一个功能性的肠道,一系列高度协调的发育过程必须发生。在这篇综述中,我们试图涵盖从原肠形成到出生的肠道发育过程中的主要事件,包括内胚层形成、肠管生长和模式、肠道形态发生、上皮重组、绒毛出现以及增殖和细胞分化。我们的讨论包括肠发育过程中的形态学和解剖学变化以及调节这些过程的分子机制。
The endoderm gives rise to the lining of the esophagus, stomach and intestines, as well as associated organs. To generate a functional intestine, a series of highly orchestrated developmental processes must occur. In this review, we attempt to cover major events during intestinal development from gastrulation to birth, including endoderm formation, gut tube growth and patterning, intestinal morphogenesis, epithelial reorganization, villus emergence as well as proliferation and cytodifferentiation. Our discussion includes morphological and anatomical changes during intestinal development as well as molecular mechanisms regulating these processes.
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