Involvement of gamma-aminobutyric acid in the stimulatory effect of metoclopramide on gastrointestinal motility.
Involvement of gamma-aminobutyric acid in the stimulatory effect of metoclopramide on gastrointestinal motility.
复制标题
γ-氨基丁酸参与甲氧氯普胺对胃肠道运动的刺激作用。
DOI：
10.1016/0024-3205(94)00814-0
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发表时间：
1994
期刊：
影响因子：
6.1
通讯作者：
D. K. Ganguly
中科院分区：
文献类型：
--
作者：
L. Chaudhuri;D. K. Ganguly
使用豚鼠肌间丛纵向肌肉制剂研究了γ-氨基丁酸（GABA）在甲氧氯普胺（MCP）对胃肠道（GI）的作用机制中的作用。 MCP 诱导肌间神经丛电诱导抽搐反应的浓度依赖性增强，并且槟榔碱和 L-2, 4-二氨基丁酸（L-DABA；GABA 摄取抑制剂）和乙二胺（EDA；GABA 释放剂）进一步增强了这种效应。 MCP的促进作用被3-巯基丙酸（3-MPA；GABA合成和释放抑制剂）和GABA脱敏后降低，但在特异性GABA受体拮抗剂甲硫荷包牡丹碱后保持不变。 GABA 脱敏和 EDA 后，MCP 诱导的未刺激制剂的收缩也有所减少，而不影响对外源乙酰胆碱 (AHc) 的反应。研究表明，GABA 在 MCP 对豚鼠肌间神经丛刺激和未刺激制剂的促进作用中发挥着重要作用。
The involvement of gamma-aminobutyric acid (GABA) in the mechanism of action of metoclopramide (MCP) on gastrointestinal (GI) tract was investigated employing guinea-pig myenteric plexus longitudinal muscle preparations. MCP induced a concentration dependent enhancement of electrically induced twitch responses of the myenteric plexus and this effect was further intensified by arecaidine and L-2, 4-diaminobutyric acid (L-DABA; GABA uptake inhibitors) and ethylenediamine (EDA;GABA releasing agent). The facilitatory effect of MCP was reduced by 3-mercaptopropionic acid (3-MPA; GABA synthesis and release inhibitor) and after GABA desensitization but remained unchanged after bicuculline methiodide, a specific GABA receptor antagonist. The MCP induced contraction of the unstimulated preparation was also reduced after GABA desensitization and EDA without affecting responces to exogenous acetylcholine (AHc). The study indicated that GABA plays a role in the facilitatory effect of MCP on both stimulated and unstimulated preparations of guineapig myenteric plexus.
γ-氨基丁酸在豚鼠回肠肌间神经丛中的作用。
影响因子：
5
作者：
Kaplita,PV;Waters,DH;Triggle,DJ
通讯作者：
Triggle,DJ