Parietal connectivity mediates multisensory facilitation.
Parietal connectivity mediates multisensory facilitation.
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DOI：
10.1016/j.neuroimage.2013.04.047
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发表时间：
2013-09
期刊：
影响因子：
5.7
通讯作者：
Ramachandran, V. S.
中科院分区：
文献类型：
--
作者：
Brang, David;Taich, Zachary J.;Hillyard, Steven A.;Grabowecky, Marcia;Ramachandran, V. S.
在日常生活中，我们的感官通过多感官整合相互作用，促进感知过程和行为反应。被认为是这种多感官促进作用基础的神经机制包括直接连接早期感觉区域的解剖学连接、到高阶多感官区域的间接连接，以及丘脑连接。在此，我们研究了通过弥散张量成像评估的白质连通性与多感官促进的个体差异之间的关系，并首次证明了在正常发育个体中解剖学连通性与多感官处理之间的关系。通过全脑分析以及对多感官处理的解剖学模型进行对比，我们发现顶叶区域和早期感觉区域之间连通性的增强与对多感官（视听）刺激的反应时间的促进有关。此外，基于先前动物研究表明上丘参与这一过程，我们利用概率纤维束成像确定，与上丘连接的最强皮质投射区域包括我们独立的全脑分析中所涉及的连通性区域。
Our senses interact in daily life through multisensory integration, facilitating perceptual processes and behavioral responses. The neural mechanisms proposed to underlie this multisensory facilitation include anatomical connections directly linking early sensory areas, indirect connections to higher-order multisensory regions, as well as thalamic connections. Here we examine the relationship between white matter connectivity, as assessed with diffusion tensor imaging, and individual differences in multisensory facilitation and provide the first demonstration of a relationship between anatomical connectivity and multisensory processing in typically developed individuals. Using a whole-brain analysis and contrasting anatomical models of multisensory processing we found that increased connectivity between parietal regions and early sensory areas was associated with the facilitation of reaction times to multisensory (auditory-visual) stimuli. Furthermore, building on prior animal work suggesting the involvement of the superior colliculus in this process, using probabilistic tractography we determined that the strongest cortical projection area connected with the superior colliculus includes the region of connectivity implicated in our independent whole-brain analysis.
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