Crucial biological functions of CCL7 in cancer.

Crucial biological functions of CCL7 in cancer.
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CCL7 在癌症中的重要生物学功能

DOI:
10.7717/peerj.4928
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发表时间:
2018
期刊:
影响因子:
2.7
通讯作者:
Xiong X
Xiong X
中科院分区:
生物学3区
文献类型:
--
作者:
Liu Y;Cai Y;Liu L;Wu Y;Xiong X

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趋化因子(C-C motif)配体7(CCL 7)是一种CC趋化因子,是多种白细胞(包括单核细胞和中性粒细胞)的趋化因子和引诱剂。CCL 7在多种细胞类型中广泛表达,并且可以通过与其受体结合来介导免疫细胞的募集而参与抗炎反应。CCL 7的异常表达与某些免疫性疾病有关。此外,CCL 7在肿瘤发生中起关键作用。CCL 7通过支持肿瘤微环境的形成和促进肿瘤侵袭和转移来促进肿瘤进展,尽管一些研究表明CCL 7具有肿瘤抑制作用。在这篇综述中,我们总结了目前可用的信息,CCL 7对肿瘤的影响。
Chemokine (C-C motif) ligand 7 (CCL7), a CC chemokine, is a chemotactic factor and attractant for various kinds of leukocytes, including monocytes and neutrophils. CCL7 is widely expressed in multiple cell types and can participate in anti-inflammatory responses through binding to its receptors to mediate the recruitment of immune cells. Abnormal CCL7 expression is associated with certain immune diseases. Furthermore, CCL7 plays a pivotal role in tumorigenesis. CCL7 promotes tumor progression by supporting the formation of the tumor microenvironment and facilitating tumor invasion and metastasis, although some studies have suggested that CCL7 has tumor suppressor effects. In this review, we summarize the currently available information regarding the influence of CCL7 on tumors.
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