The lipopolysaccharide export pathway in Escherichia coli: structure, organization and regulated assembly of the Lpt machinery.

The lipopolysaccharide export pathway in Escherichia coli: structure, organization and regulated assembly of the Lpt machinery.
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DOI:
10.3390/md12021023
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发表时间:
2014-02-17
期刊:
影响因子:
5.4
通讯作者:
Sperandeo P
Sperandeo P
中科院分区:
医学2区
文献类型:
--
作者:
Polissi A;Sperandeo P

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The bacterial outer membrane (OM) is a peculiar biological structure with a unique composition that contributes significantly to the fitness of Gram-negative bacteria in hostile environments. OM components are all synthesized in the cytosol and must, then, be transported efficiently across three compartments to the cell surface. Lipopolysaccharide (LPS) is a unique glycolipid that paves the outer leaflet of the OM. Transport of this complex molecule poses several problems to the cells due to its amphipatic nature. In this review, the multiprotein machinery devoted to LPS transport to the OM is discussed together with the challenges associated with this process and the solutions that cells have evolved to address the problem of LPS biogenesis.
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