Intact internal dynamics of the neocortex in acutely paralyzed mice
Intact internal dynamics of the neocortex in acutely paralyzed mice
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急性瘫痪小鼠新皮质的完整内部动力学
DOI：
10.1007/s12576-011-0155-x
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发表时间：
2011
影响因子：
2.3
通讯作者：
Ikegaya Y
中科院分区：
文献类型：
--
作者：
Minamisawa G;Funayama K;Matsuki N;Ikegaya Y
动物通过自我产生的动作收集感觉信息。肌肉运动驱动感觉信息的主动反馈，并决定动物接收的大部分感觉输入；然而，人们对这种主动反馈过程如何调节大脑的持续动态知之甚少。我们对小鼠新皮层2/3层神经元进行了电生理记录，比较了正常和低张力状态下局部场电位和细胞内电位波动的自发皮层活动。我们发现，pancuronium诱导的麻痹并不影响正在进行的皮层活动及其由视觉和触觉刺激引起的扰动的电生理特性。因此，至少在急性期，活跃的肌肉运动对内部皮质动力学的影响不大。
Animals collect sensory information through self-generated movements. Muscle movements drive active feedback of sensory information and determine large parts of the sensory inputs the animal receives; however, little is known about how this active feedback process modulates the ongoing dynamics of the brain. We made electrophysiological recordings from layer 2/3 neurons of the mouse neocortex and compared spontaneous cortical activity in local field potentials and intracellular potential fluctuations between normal and hypomyotonic conditions. We found that pancuronium-induced paralysis did not affect the electrophysiological properties of ongoing cortical activity and its perturbation evoked by visual and tactile stimuli. Thus, internal cortical dynamics are not much affected by active muscle movements, at least, in an acute phase.
鞘内注射肌肉松弛剂对大鼠中枢神经系统的影响
影响因子：
5.7
作者：
J. Szenohradszky;A. Trevor;P. Bickler;J. Caldwell;M. Sharma;I. Rampil;Ronald D. Miller
通讯作者：
Ronald D. Miller
人脑脊液中 d-管箭毒碱的水平
影响因子：
8.8
作者：
R. Matteo;E. K. Pua;H. Khambatta
通讯作者：
H. Khambatta
d-管箭毒碱直接注射到大鼠大脑中会导致神经元死亡
影响因子：
5.3
作者：
R. Dasheiff
通讯作者：
R. Dasheiff