Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth.
Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth.
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DOI：
10.1007/s00787-020-01653-x
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发表时间：
2021-12
影响因子：
6.4
通讯作者：
Salum, Giovanni Abrahao
中科院分区：
文献类型：
--
作者：
Axelrud, Luiza Kvitko;Simioni, Andre Rafael;Pine, Daniel Samuel;Winkler, Anderson Marcelo;Pan, Pedro Mario;Sato, Joao Ricardo;Zugman, Andre;Parker, Nadine;Picon, Felipe;Jackowski, Andrea;Hoexter, Marcelo Queiroz;Barker, Gareth;Martinot, Jean-Luc;Martinot, Marie Laure Paillere;Satterthwaite, Theodore;Rohde, Luis Augusto;Milham, Michael;Barker, Edward Dylan;Salum, Giovanni Abrahao
在遗传学中，将多个效应值较小的基因座聚集到一个单独的分数中可以提高预测能力。然而，研究应用容易复制加权评分神经影像学数据是缺乏的。我们的目的是评估神经影像学关联评分（NAS）的可靠性和有效性，该评分结合了先前与精神障碍相关的结构性大脑特征的信息。参与者是来自巴西两个城市的726名青少年（6-14岁），他们在基线时接受了MRI和精神病理学评估，在3年随访时接受了387次评估。结果在两个样本中重复：IMAGEN（n = 1627）和健康大脑网络（n = 843）。NAS是通过将每个标准化大脑特征的乘积与该大脑特征与先前荟萃分析记录的7种精神疾病的关联的效应量相加而得出的。使用T1加权扫描计算表面积、皮质厚度和皮质下体积的NAS。分析NAS信度、时间稳定性、精神病理学和认知预测。NAS的表面积表现出较高的内部一致性和3年的稳定性，并预测一般的精神病理学和认知具有较高的可复制性比特定的症状领域的所有样本。他们还预测了一般的精神病理学，其可复制性高于单独的单一结构，占方差的1-3%，但没有方向性。皮质厚度和皮质下体积的NAS表现出较低的内部一致性和较少的可复制的关联与行为表型。这些发现表明，基于表面积的NAS可能是一般精神病理学的可复制标记，但这些联系不太可能是因果关系或临床有用的。
In genetics, aggregation of many loci with small effect sizes into a single score improved prediction. Nevertheless, studies applying easily replicable weighted scores to neuroimaging data are lacking. Our aim was to assess the reliability and validity of the Neuroimaging Association Score (NAS), which combines information from structural brain features previously linked to mental disorders. Participants were 726 youth (aged 6–14) from two cities in Brazil who underwent MRI and psychopathology assessment at baseline and 387 at 3-year follow-up. Results were replicated in two samples: IMAGEN (n = 1627) and the Healthy Brain Network (n = 843). NAS were derived by summing the product of each standardized brain feature by the effect size of the association of that brain feature with seven psychiatric disorders documented by previous meta-analyses. NAS were calculated for surface area, cortical thickness and subcortical volumes using T1-weighted scans. NAS reliability, temporal stability and psychopathology and cognition prediction were analyzed. NAS for surface area showed high internal consistency and 3-year stability and predicted general psychopathology and cognition with higher replicability than specific symptomatic domains for all samples. They also predicted general psychopathology with higher replicability than single structures alone, accounting for 1–3% of the variance, but without directionality. The NAS for cortical thickness and subcortical volumes showed lower internal consistency and less replicable associations with behavioural phenotypes. These findings indicate the NAS based on surface area might be replicable markers of general psychopathology, but these links are unlikely to be causal or clinically useful yet.
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影响因子：
--
作者：
Koutsouleris, Nikolaos;Meisenzahl, Eva M.;Davatzikos, Christos;Bottlender, Ronald;Frodl, Thomas;Scheuerecker, Johanna;Schmitt, Gisela;Zetzsche, Thomas;Decker, Petra;Reiser, Maximilian;Moeller, Hans-Juergen;Gaser, Christian
通讯作者：
Gaser, Christian
DOI：
10.1176/appi.ajp.2015.14091200
发表时间：
2016-04-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Clementz BA;Sweeney JA;Hamm JP;Ivleva EI;Ethridge LE;Pearlson GD;Keshavan MS;Tamminga CA
通讯作者：
Tamminga CA
DOI：
10.1093/brain/awp123
发表时间：
2009-08
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Desikan RS;Cabral HJ;Hess CP;Dillon WP;Glastonbury CM;Weiner MW;Schmansky NJ;Greve DN;Salat DH;Buckner RL;Fischl B;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
3.3
作者：
Bitsakou, P.;Psychogiou, L.;Sonuga-Barke, E. J. S.
通讯作者：
Sonuga-Barke, E. J. S.
影响因子：
17.7
作者：
Hoogman, Martine;Muetzel, Ryan;Franke, Barbara
通讯作者：
Franke, Barbara