In situ mechanical behavior of mineral crystals in human cortical bone under compressive load using synchrotron X-ray scattering techniques.
In situ mechanical behavior of mineral crystals in human cortical bone under compressive load using synchrotron X-ray scattering techniques.
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DOI：
10.1016/j.jmbbm.2012.05.003
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发表时间：
2012-10
影响因子：
3.9
通讯作者：
Wang, Xiaodu
中科院分区：
文献类型：
--
作者：
Giri, Bijay;Almer, Jonathan D.;Dong, X. Neil;Wang, Xiaodu
矿物晶体是骨的主要承载成分，在骨组织中以(00l)轴优先沿纵轴排列，与晶体各向异性共同导致力学行为的宏观各向异性。因此，描述矿物晶体的不同子集作为取向的函数对骨的整体力学行为的贡献是非常有意义的。采用一种独特的协同方法，结合渐进加载方案和同步辐射X射线散射技术，对人皮质骨标本进行压缩加载，以考察矿物晶体的原位力学行为随取向的变化。通过测量不同取向的(002)晶面的X射线衍射强度，定量地估计了矿物晶体的取向分布。此外，通过测量垂直于三个不同晶面(即002、310和213)的晶体中的晶格变形，确定了沿每个方向排列的矿物晶体子集的平均纵向(c轴)、横向(a轴)和剪切应变。实验结果表明，矿物晶体的原位应变和应力随取向不同而不同。纵向取向的矿物晶体的法向应变和应力明显大于横向取向的晶体，而与加载方向成±30°方向排列的晶体的剪应力最大，与骨长轴方向一致。在沿加载轴方向取向的矿物晶体中观察到最大主应变和最大应力，最大剪切应变和最大应力也有类似的趋势。通过研究矿物晶体的原位行为，讨论了矿物晶体对承载和骨的体积行为的贡献。
Mineral crystals, the major strength-bearing component of bone, are aligned in longitudinal bone with (00l) axes preferentially along the longitudinal axis, which in concert with crystal anisotropy leads to macroscopic anisotropy in mechanical behavior. Thus, it is of great interest to delineate the contributions of different subsets of mineral crystals as a function of orientation, on the bulk mechanical behavior of bone. Using a unique synergistic approach combining a progressive loading scheme and synchrotron X-ray scattering techniques, human cortical bone specimens were loaded in compression to examine the in situ mechanical behavior of mineral crystals as the function of orientation. The orientation distribution of mineral crystals was quantitatively estimated by measuring the X-ray diffraction intensity from the crystallographic (002) plane in different orientations. In addition, the average longitudinal (c-axis), transverse (a-axis), and shear strains of the subset of mineral crystals aligned in each orientation were determined by measuring the lattice deformation in the crystals normal to three distinct crystallographic planes (i.e. 002, 310, and 213). The experimental results indicated that the in situ strain and stress of mineral crystals varied with orientation. The normal strain and stress exerted on the longitudinally aligned mineral crystals were markedly greater than those on the transversely oriented crystals, whereas the shear stress reached a maximum for the crystals aligned in ±30° with respect to the loading direction, which coincided with the long axis of bone. The maximum principal strain and stress were observed in the mineral crystals oriented along the loading axis, with a similar trend observed in the maximum shear strain and stress. By examining their in situ behavior, the contribution of mineral crystals to load bearing and the bulk behavior of bone are discussed.
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影响因子：
2.4
作者：
Fujisaki, Kazuhiro;Tadano, Shigeru
通讯作者：
Tadano, Shigeru
影响因子：
9.7
作者：
Akhtar, R.;Daymond, M. R.;Mummery, P. M.
通讯作者：
Mummery, P. M.
DOI：
10.1016/0169-6009(92)90710-u
发表时间：
1992-04-01
期刊：
BONE AND MINERAL
影响因子：
--
作者：
LEES, S;HUKINS, DWL
通讯作者：
HUKINS, DWL
影响因子：
4.1
作者：
HANDSCHIN, RG;STERN, WB
通讯作者：
STERN, WB
影响因子：
3
作者：
Almer, JD;Stock, SR
通讯作者：
Stock, SR