NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes.
NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes.
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DOI：
10.1042/bcj20220075
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发表时间：
2022-06-17
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核酪蛋白和细胞周期蛋白依赖性激酶底物1(NUCKS1)蛋白在脊椎动物中高度保守，主要定位于细胞核，是人类蛋白质组中修饰最严重的蛋白质之一。NUCKS1在干细胞和大脑中的表达很高，在小鼠中受到发育调节，并与人类的几种不同的恶性肿瘤有关，包括癌症、代谢综合征和帕金森病。NUCKS1的功能与调节染色质结构和转录、DNA修复和细胞周期调节有关。在这篇综述中，我们总结和讨论了关于NUCKS1的已发表的信息，并强调了为了更好地理解这种多方面蛋白质的复杂生物学而有待解决的问题。
The Nuclear Casein and Cyclin-dependent Kinase Substrate 1 (NUCKS1) protein is highly conserved in vertebrates, predominantly localized to the nucleus and one of the most heavily modified proteins in the human proteome. NUCKS1 expression is high in stem cells and the brain, developmentally regulated in mice and associated with several diverse malignancies in humans, including cancer, metabolic syndrome, and Parkinson’s disease. NUCKS1 function has been linked to modulating chromatin architecture and transcription, DNA repair and cell cycle regulation. In this review, we summarize and discuss the published information on NUCKS1 and highlight the questions that remain to be addressed to better understand the complex biology of this multifaceted protein.
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作者：
Ziółkowski P;Gamian E;Osiecka B;Zougman A;Wiśniewski JR
通讯作者：
Wiśniewski JR