Manipulation of Regulatory Dendritic Cells for Induction Transplantation Tolerance.
Manipulation of Regulatory Dendritic Cells for Induction Transplantation Tolerance.
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操纵调节性树突状细胞以诱导移植耐受性。
DOI：
10.3389/fimmu.2020.582658
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发表时间：
2020
影响因子：
7.3
通讯作者：
Li XK
中科院分区：
文献类型：
--
作者：
Que W;Guo WZ;Li XK
当前的器官移植疗法可挽救生命，但由于移植后的系统性免疫抑制治疗，会伴有众所周知的副作用。树突状细胞（DCs）是移植免疫的核心引发者和调节者，负责平衡同种异体移植物的排斥和耐受。它们来源于骨髓中的单核巨噬细胞 - 树突状细胞祖细胞，并根据其发育、表型和功能标准分为不同的亚群。在功能上，树突状细胞通过直接、间接和半直接识别途径将供体抗原呈递给同种反应性T细胞，从而引发同种异体移植物免疫，并通过共刺激分子和促炎细胞因子为同种反应性T细胞的激活提供必要的信号。调节性树突状细胞（DCregs）的特征是主要组织相容性复合体和共刺激分子表达相对较低，细胞因子产生改变，并通过T细胞无能、T细胞缺失和调节性T细胞诱导发挥其调节功能。在啮齿动物移植研究中，基于DCregs的疗法，通过原位靶向或输注体外产生的DCregs，作为一种天然的、耐受性良好的、器官特异性的治疗策略，在促进持久的器官特异性移植耐受方面显示出有前景的潜力。近期对DCregs的早期研究已开始检验DCregs诱导的同种异体移植物耐受在活体供肾或肝移植中的安全性和有效性。本综述总结了DCregs在诱导移植耐受方面的基本特征、功能及其转化应用。
Current organ transplantation therapy is life-saving but accompanied by well-recognized side effects due to post-transplantation systematic immunosuppressive treatment. Dendritic cells (DCs) are central instigators and regulators of transplantation immunity and are responsible for balancing allograft rejection and tolerance. They are derived from monocyte-macrophage DC progenitors originating in the bone marrow and are classified into different subsets based on their developmental, phenotypical, and functional criteria. Functionally, DCs instigate allograft immunity by presenting donor antigens to alloreactive T cells via direct, indirect, and semidirect recognition pathways and provide essential signaling for alloreactive T cell activation via costimulatory molecules and pro-inflammatory cytokines. Regulatory DCs (DCregs) are characterized by a relatively low expression of major histocompatibility complex, costimulatory molecules, and altered cytokine production and exert their regulatory function through T cell anergy, T cell deletion, and regulatory T cell induction. In rodent transplantation studies, DCreg-based therapy, by in situ targeting or infusion of ex vivo generated DCregs, exhibits promising potential as a natural, well-tolerated, organ-specific therapeutic strategy for promoting lasting organ-specific transplantation tolerance. Recent early-phase studies of DCregs have begun to examine the safety and efficacy of DCreg-induced allograft tolerance in living-donor renal or liver transplantations. The present review summarizes the basic characteristics, function, and translation of DCregs in transplantation tolerance induction.
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影响因子：
7.3
作者：
Clayton K;Vallejo AF;Davies J;Sirvent S;Polak ME
通讯作者：
Polak ME
iPSC 衍生的调节性树突细胞通过生成同种异体抗原特异性调节性 T 细胞来抑制同种异体移植排斥
影响因子：
5.9
作者：
Cai S;Hou J;Fujino M;Zhang Q;Ichimaru N;Takahara S;Araki R;Lu L;Chen JM;Zhuang J;Zhu P;Li XK
通讯作者：
Li XK
影响因子：
15.3
作者：
Bonifaz, L;Bonnyay, D;Mahnke, K;Rivera, M;Nussenzweig, MC;Steinman, RM
通讯作者：
Steinman, RM
影响因子：
2.8
作者：
Benichou G;Yamada Y;Yun SH;Lin C;Fray M;Tocco G
通讯作者：
Tocco G
DOI：
10.1084/jem.192.12.1685
发表时间：
2000-12-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
den Haan JM;Lehar SM;Bevan MJ
通讯作者：
Bevan MJ