Kaposi's sarcoma: a review of gene expression and ultrastructure of KS spindle cells in vivo.

Kaposi's sarcoma: a review of gene expression and ultrastructure of KS spindle cells in vivo.
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卡波西肉瘤:体内 KS 梭形细胞基因表达和超微结构的综述。

DOI:
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发表时间:
1992
影响因子:
1.5
通讯作者:
Roth Wk
Roth Wk
中科院分区:
医学4区
文献类型:
--
作者:
Michael Stürzl;Heinz Brandstetter;Roth Wk

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The ultrastructural features and the gene expression pattern of Kaposi's sarcoma (KS) spindle cells in vivo suggest that KS is a tumor of the mixed cell type. The expression pattern of cytokines and cytokine receptors in the tumor lesion, together with the results obtained from in vitro characterization of KS-derived cells, provide evidence that paracrine mechanisms of growth factor action are important for the maintenance of KS. The reports on virus infection of KS cells suggest an indirect role of virus infection in the induction of KS, most likely mediated by immunostimulation and subsequent production of cytokines.
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