Are the Associations between Life-style Related Factors and Plasma Total Homocysteine Concentration Different According to Polymorphism of 5,10-Methylenetetrahydrofolate Reductase Gene (C677T MTHFR)?
Are the Associations between Life-style Related Factors and Plasma Total Homocysteine Concentration Different According to Polymorphism of 5,10-Methylenetetrahydrofolate Reductase Gene (C677T MTHFR)?
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根据 5,10-亚甲基四氢叶酸还原酶基因 (C677T MTHFR) 的多态性，生活方式相关因素与血浆总同型半胱氨酸浓度之间的关联是否有所不同？
作者：
H. Lwin;T. Yokoyama;C. Date;N. Yoshiike;Y. Kokubo;Heizo Tanaka
轻度高同型半胱氨酸血症是动脉粥样硬化性疾病的重要危险因素之一，因此明确血浆总同型半胱氨酸（tHcy）水平的影响因素具有重要意义。2000年，对455名年龄在40-69岁的日本农村居民进行了一项随机抽样的横断面研究，以调查血浆tHcy浓度与5，10-亚甲基四氢叶酸还原酶（MTHFR）基因和选定的生活方式相关因素的关系。突变等位基因频率为0.40，VV基因型的发生率为14.3%。VV型血浆tHcy浓度显著高于其他两种基因型。血浆tHcy与血清叶酸和血清维生素B12呈显著负相关（趋势分别为P<0.001），VV基因型的tHcy与血清叶酸和维生素B12呈显著负相关（趋势分别为P<0.001）。每天吸烟的数量与血浆tHcy浓度呈正相关。多因素回归分析显示血清叶酸、血清维生素B12和MTHFR基因型与血浆tHcy独立相关。血清叶酸和维生素B12对血浆tHcy的个体间差异的解释力大于MTHFR基因型。高叶酸、维生素B12的摄入量和不吸烟可能对预防轻度高同型半胱氨酸血症和日本农村人群最终的动脉粥样硬化疾病很重要。
Mild hyperhomocysteinemia is one of the known strong risk factors for atherosclerotic diseases, and therefore it is important to clarify factors that could determine plasma total homocysteine (tHcy) level. A cross-sectional study with a random sample of 455 Japanese rural residents aged 40-69 years was conducted in 2000 to investigate the associations of plasma tHcy concentration with 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and selected life-style related factors. The frequency of the mutant allele, Valine (V) allele, was 0.40 and the prevalence of VV genotype was 14.3 %. Plasma tHcy concentration in VV was significantly higher than those in two other genotypes. There were significant inverse associations of plasma tHcy with serum folate and serum vitamin B12 (P<0.001 for trend, respectively); both being stronger in VV than in other genotypes. The number of cigarettes smoked per day was positively associated with plasma tHcy concentration. A multivariate regression analysis revealed that serum folate, serum vitamin B12, and MTHFR genotype were independently associated with plasma tHcy. The inter-individual variance of plasma tHcy was more explained by serum folate and vitamin B12 than by MTHFR genotype. Higher intakes of folate, vitamin B12, and non-smoking may be important to prevent mild hyperhomocysteinemia and the eventual atherosclerotic diseases in this Japanese rural population.
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DOI：
10.1001/jama.1992.03490070059042
发表时间：
1992-08
期刊：
JAMA
影响因子：
--
作者：
M. Stampfer;M. Malinow;W. Willett;L. Newcomer;B. Upson;D. Ullmann;P. Tishler;C. Hennekens
通讯作者：
M. Stampfer;M. Malinow;W. Willett;L. Newcomer;B. Upson;D. Ullmann;P. Tishler;C. Hennekens
影响因子：
37.8
作者：
Jacques, PF;Bostom, AG;Rozen, R
通讯作者：
Rozen, R
影响因子：
7.1
作者：
PIYATHILAKE, CJ;MACALUSO, M;KRUMDIECK, CL
通讯作者：
KRUMDIECK, CL
影响因子：
37.8
作者：
Ma, J;Stampfer, MJ;Rozen, R
通讯作者：
Rozen, R
DOI：
10.1249/00005768-199301000-00011
发表时间：
1993-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
AINSWORTH, BE;HASKELL, WL;PAFFENBARGER, RS
通讯作者：
PAFFENBARGER, RS