Iron Metabolism and Ferroptosis in Epilepsy.
Iron Metabolism and Ferroptosis in Epilepsy.
复制标题
癫痫中的铁代谢和铁死亡
DOI：
10.3389/fnins.2020.601193
复制
发表时间：
2020
影响因子：
4.3
通讯作者：
Li Q
中科院分区：
文献类型：
--
作者：
Chen S;Chen Y;Zhang Y;Kuang X;Liu Y;Guo M;Ma L;Zhang D;Li Q
癫痫是一种以脑神经元过度同步放电导致的复发性、阵发性和短暂性中枢神经系统（CNS）功能障碍为特征的疾病。其特点是病因多样、发病机制复杂、治疗困难。此外，大多数癫痫患者表现出社会认知障碍和心理障碍。铁是人体生长发育必需的微量元素，还参与生物体内多种氧化还原反应。然而，铁代谢异常与多种神经系统疾病有关，包括出血性中风后癫痫和创伤后癫痫（PTE）。此外，铁死亡也被认为是细胞死亡调节的一种新形式，其归因于多种神经系统疾病（包括癫痫）中发现的活性氧（ROS）的产生和铁超载引起的严重脂质过氧化。因此，本文对铁代谢与癫痫铁死亡的研究进行综述，以期阐明铁与癫痫的相关性。也为癫痫的治疗、预防和研究提供了新的方法，控制癫痫发作，减少癫痫发作后的神经损伤。
Epilepsy is a disease characterized by recurrent, episodic, and transient central nervous system (CNS) dysfunction resulting from an excessive synchronous discharge of brain neurons. It is characterized by diverse etiology, complex pathogenesis, and difficult treatment. In addition, most epileptic patients exhibit social cognitive impairment and psychological impairment. Iron is an essential trace element for human growth and development and is also involved in a variety of redox reactions in organisms. However, abnormal iron metabolism is associated with several neurological disorders, including hemorrhagic post-stroke epilepsy and post-traumatic epilepsy (PTE). Moreover, ferroptosis is also considered a new form of regulation of cell death, which is attributed to severe lipid peroxidation caused by the production of reactive oxygen species (ROS) and iron overload found in various neurological diseases, including epilepsy. Therefore, this review summarizes the study on iron metabolism and ferroptosis in epilepsy, in order to elucidate the correlation between iron and epilepsy. It also provides a novel method for the treatment, prevention, and research of epilepsy, to control epileptic seizures and reduce nerve injury after the epileptic seizure.
登录
查看更多内容
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
11.4
作者：
DeGregorio-Rocasolano N;Martí-Sistac O;Ponce J;Castelló-Ruiz M;Millán M;Guirao V;García-Yébenes I;Salom JB;Ramos-Cabrer P;Alborch E;Lizasoain I;Castillo J;Dávalos A;Gasull T
通讯作者：
Gasull T
影响因子：
13.8
作者：
Bogdan AR;Miyazawa M;Hashimoto K;Tsuji Y
通讯作者：
Tsuji Y
影响因子：
9.5
作者：
Abbina, Srinivas;Gill, Arshdeep;Kizhakkedathu, Jayachandran N.
通讯作者：
Kizhakkedathu, Jayachandran N.
影响因子：
3.6
作者：
Das, Jharana;Singh, Rameshwar;Sharma, Deepak
通讯作者：
Sharma, Deepak