Transmural Oxygen Tension Gradients in Rat Cerebral Cortex Arterioles

Transmural Oxygen Tension Gradients in Rat Cerebral Cortex Arterioles
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大鼠大脑皮层小动脉的透壁氧张力梯度

DOI:
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发表时间:
2009
影响因子:
--
通讯作者:
E. Vovenko
E. Vovenko
中科院分区:
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作者:
E. Vovenko

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采用改良针式氧微电极和活体显微镜测量软脑膜小动脉的跨壁氧分压梯度(PO 2),管腔直径为20-90 μm。发现透壁PO 2梯度的大小与小动脉壁张力之间存在关系:在对照条件下,PO 2梯度为1.17 ± 0.06 mmHg/μm(n = 40),而在小动脉壁扩张条件下,透壁PO 2梯度降至0.68 ± 0.04 mmHg/μm(p < 0.001,n = 38)。这些数据提供了第一次测量的跨壁PO 2梯度在不同口径的软脑膜小动脉在不同水平的血管紧张度,并具有根本的重要性,动脉微血管在组织供氧过程中的作用进行评估。这里获得的结果提供了证据,证明血管壁的耗氧量在包被组织的特征范围内,并且内皮细胞层的耗氧量可能对跨壁PO 2梯度的大小没有显着影响。
Modified needle oxygen microelectrodes and vital microscopy were used to measure transmural oxygen tension gradients (PO2) in pial arterioles with lumen diameters of 20–90  μm. A relationship between the magnitude of the transmural PO2 gradient and arteriole wall tone was found: in control conditions, PO2 gradients were 1.17 ± 0.06 mmHg/μm (n  = 40), while in conditions of arteriolar wall dilation the transmural PO2 gradient decreased to 0.68 ± 0.04 mmHg/μm (p  <  0.001, n  = 38). These data provide the first measurements of transmural PO2 gradients in pial arterioles of different calibers at different levels of vascular tone and have fundamental importance for assessing the role of arterial microvessels in tissue oxygen supply processes. The results obtained here provide evidence that oxygen consumption by the vessel wall is within the range characteristic of enveloping tissues and that oxygen consumption by the endothelial cell layer probably has no significant effect on the magnitude of the transmural PO2 gradient.
DOI: 10.1016/0883-9441(89)90050-6
发表时间: 1989-03
期刊: The American journal of physiology
影响因子: --
作者:
Aleksander S. Popel;Roland N. Pittman;M. Ellsworth
通讯作者: Aleksander S. Popel;Roland N. Pittman;M. Ellsworth
组织中氧张力的测量。
DOI: --
发表时间: 1990
期刊: Nursing research
影响因子: 2.5
作者:
Whitney,JD
通讯作者: Whitney,JD
嵌入式氧电极:获取超过 PO2。
DOI: 10.1007/978-1-4615-0205-0_29
发表时间: 2003
影响因子: --
作者:
Buerk,DonaldG
通讯作者: Buerk,DonaldG