Vaccine approaches conferring cross-protection against influenza viruses.
Vaccine approaches conferring cross-protection against influenza viruses.
复制标题
DOI：
10.1080/14760584.2017.1379396
复制
发表时间：
2017-11
影响因子：
6.2
通讯作者：
Mittal SK
中科院分区：
文献类型：
--
作者：
Vemula SV;Sayedahmed EE;Sambhara S;Mittal SK
每年接种疫苗是预防和控制流感流行的最有效和最具成本效益的策略之一。目前可用的大多数流感疫苗是针对病毒表面蛋白、血凝素（HA）和神经氨酸酶（NA）的抗体应答的强诱导剂，但是针对保守的内部蛋白的细胞介导的免疫应答的弱诱导剂。此外，由于抗原漂移或抗原转变导致病毒表面蛋白的高度可变性，许多目前许可的疫苗对漂移或转变变体几乎没有保护作用或没有保护作用。下一代流感疫苗可诱导对受体结合表位的体液免疫应答以及广泛中和保守表位，以及对高度保守的内部蛋白质的细胞介导的免疫应答，其将有效对抗变异病毒以及新型大流行性流感，直到流行株特异性疫苗变得可用。在这里，我们讨论了疫苗的方法，有可能提供广谱保护流感病毒。根据目前在定义交叉保护性流感免疫方面的进展，似乎开发通用流感疫苗是可行的。它将彻底改变流感大流行防范战略，并对季节性流感疫苗的保质期和保护效力产生重大影响。
Annual vaccination is one of the most efficient and cost-effective strategies to prevent and control influenza epidemics. Most of currently available influenza vaccines are strong inducer of antibody responses against viral surface proteins, hemagglutinin (HA) and neuraminidase (NA), but are poor inducers of cell-mediated immune responses against conserved internal proteins. Moreover, due to the high variability of viral surface proteins because of antigenic drift or antigenic shift, many of the currently licensed vaccines confer little or no protection against drift or shift variants. Next generation influenza vaccines that can induce humoral immune responses to receptor-binding epitopes as well as broadly neutralizing conserved epitopes, and cell-mediated immune responses against highly conserved internal proteins would be effective against variant viruses as well as a novel pandemic influenza until circulating strain-specific vaccines become available. Here we discuss vaccine approaches that have potential to provide broad spectrum protection against influenza viruses. Based on current progress in defining cross-protective influenza immunity, it seems that the development of a universal influenza vaccine is feasible. It would revolutionize the strategy for influenza pandemic preparedness, and significantly impact the shelf-life and protection efficacy of seasonal influenza vaccines.
登录
查看更多内容
影响因子：
17.1
作者：
Andrews SF;Huang Y;Kaur K;Popova LI;Ho IY;Pauli NT;Henry Dunand CJ;Taylor WM;Lim S;Huang M;Qu X;Lee JH;Salgado-Ferrer M;Krammer F;Palese P;Wrammert J;Ahmed R;Wilson PC
通讯作者：
Wilson PC
影响因子：
12.4
作者：
Antrobus, Richard D.;Berthoud, Tamara K.;Gilbert, Sarah C.
通讯作者：
Gilbert, Sarah C.
影响因子：
6.4
作者：
Chen, Yixin;Qin, Kun;Xia, Ningshao
通讯作者：
Xia, Ningshao
影响因子：
4.4
作者：
El Bakkouri, Karim;Descamps, Francis;Saelens, Xavier
通讯作者：
Saelens, Xavier
DOI：
10.1177/2051013615595595
发表时间：
2015-07-01
期刊：
Therapeutic advances in vaccines
影响因子：
--
作者：
Cox, Manon M J;Izikson, Ruvim;Dunkle, Lisa
通讯作者：
Dunkle, Lisa