A Novel Analysis of Compound Muscle Action Potential Scan: Staircase Function Fitting and StairFit Motor Unit Number Estimation.
A Novel Analysis of Compound Muscle Action Potential Scan: Staircase Function Fitting and StairFit Motor Unit Number Estimation.
复制标题
DOI：
10.1109/jbhi.2022.3229211
复制
发表时间：
2023-03
影响因子：
7.7
通讯作者：
Zhou, Ping
中科院分区：
文献类型：
--
作者：
Chen, Maoqi;Lu, Zhiyuan;Zong, Ya;Li, Xiaoyan;Zhou, Ping
关键词：
复合肌肉动作电位(CMAP)扫描为神经肌肉疾病的检查提供了详细的刺激-反应曲线。该研究的目的是开发一种新的CMAP扫描分析来提取运动单位数量估计(MUNE)和其他生理或诊断信息。使用阶梯函数作为CMAP扫描的基本数学模型。对于每个给定的电机单元数，估计一个最优的阶梯函数拟合模型，并接受满足预定误差要求的最小电机单元数的拟合模型。这会产生MUNE以及每个运动单位的尖峰幅度和激活阈值，这些都是CMAP扫描的组成部分。通过使用不同电机单元编号(20、50、100和150)和基线噪声(1µV、5µV和10µV)输入的模拟CMAP扫描，从MUNE性能、重复性和重测可靠性方面证实了阶梯功能匹配的重要性。在实验数据中，脊髓损伤受试者第一骨间背侧肌经阶梯功能拟合后的MUNE平均值为57.5%±26.9%，显著低于对照组的101.2±16.9%(p<；0.001)。阶梯函数拟合为CMAP的扫描处理提供了一种合适的方法，产生了MUNE和其他用于检查运动单位丢失和肌纤维再支配的有用参数。
Compound muscle action potential (CMAP) scan provides a detailed stimulus-response curve for examination of neuromuscular disease. The objective of the study is to develop a novel CMAP scan analysis to extract motor unit number estimation (MUNE) and other physiological or diagnostic information. A staircase function was used as the basic mathematical model of the CMAP scan. An optimal staircase function fitting model was estimated for each given number of motor units, and the fitting model with the minimum number of motor units that meets a predefined error requirement was accepted. This yields MUNE as well as the spike amplitude and activation threshold of each motor unit that contributes to the CMAP scan. The significance of the staircase function fit was confirmed using simulated CMAP scans with different motor unit number (20, 50, 100 and 150) and baseline noise (1 µV, 5 µV and 10 µV) inputs, in terms of MUNE performance, repeatability, and the test-retest reliability. For experimental data, the average MUNE of the first dorsal interosseous muscle derived from the staircase function fitting was 57.5 ± 26.9 for the tested spinal cord injury subjects, which was significantly lower than 101.2 ± 16.9, derived from the control group (p < 0.001). The staircase function fitting provides an appropriate approach to CMAP scan processing, yielding MUNE and other useful parameters for examination of motor unit loss and muscle fiber reinnervation.
登录
查看更多内容
影响因子：
4
作者：
Major, Lora A.;Jones, Kelvin E.
通讯作者：
Jones, Kelvin E.
DOI：
10.1111/j.1467-9876.2007.00576.x
发表时间：
2007-01-01
影响因子：
1.6
作者：
Ridall, P. G.;Pettitt, A. N.;Henderson, R. D.
通讯作者：
Henderson, R. D.
影响因子：
3.4
作者：
WANG, FC;DELWAIDE, PJ
通讯作者：
DELWAIDE, PJ
影响因子：
2.2
作者：
Xiong, G-X;Zhang, J-W;Guan, H.
通讯作者：
Guan, H.
影响因子：
4.6
作者：
Lu, Zhiyuan;Chen, Maoqi;Zhou, Ping
通讯作者：
Zhou, Ping