Synthesis and radioluminescence of PEGylated Eu(3+) -doped nanophosphors as bioimaging probes.
Synthesis and radioluminescence of PEGylated Eu(3+) -doped nanophosphors as bioimaging probes.
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DOI：
10.1002/adma.201100919
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发表时间：
2011-06-24
影响因子：
29.4
通讯作者：
Xing, Lei
中科院分区：
文献类型：
--
作者：
Sun, Conroy;Pratx, Guillem;Carpenter, Colin M.;Liu, Hongguang;Cheng, Zhen;Gambhir, Sanjiv Sam;Xing, Lei
NIH-PA作者Mandarin pt量子点（QD），这些发光纳米晶体提供了几个优势，传统的有机荧光团，包括高光化学稳定性，大斯托克斯位移，和可调的荧光发射。[1]能够吸收两个或更多个低能量光子以发射较高能量光子的上转换纳米荧光粉也表现出有利的特性，例如长荧光寿命、无光闪烁和减少的自发荧光。[2]最近开发的镧系元素掺杂的纳米荧光粉，其功能在近红外（NIR）光谱范围内最佳的光学传输通过生物组织（650-900 nm）已经吸引了极大的兴趣，在体内生物成像探针。[3-5]可替代地，目前在医学成像模态（诸如X射线计算机断层扫描（CT）或正电子发射断层扫描（PET））中采用的高能辐射也可以用于激发发射NIR的放射性发光纳米磷光体（RLNP）以用于生物成像。例如X射线发光计算机断层摄影（XLCT）。[6-8]这种创新的成像技术提供了深入的组织穿透，避免了组织自发荧光，并通过平面图像的光学重建简化了成像。这些RLNP通过分子靶向策略的组织特异性积累[9，10]将允许通过检测由窄准直X射线诱导的发光来定位病变，例如肿瘤。此外，能够被放射性同位素（例如PET示踪剂和放射性药物）激活的RLNP可以实现放射疗法的平面光学检测或分子靶标的共定位。为了使这些新的成像方式，我们提出了一个简单的程序来合成聚（乙二醇）（PEG）-涂层RLNP和检查他们的能力，作为X射线或放射性同位素激发的光学探针。
NIH-PA Author Manuscript quantum dots (QDs), these luminescent nanocrystals offer several advantages over conventional organic fluorophores, including high photochemical stability, large Stokes shift, and tunable fluorescence emission.[1] Up-conversion nanophosphors, which are capable of absorbing two or more low-energy photons to emit a higher-energy photon, also exhibit favorable characteristics such as long fluorescence lifetimes, no photoblinking, and reduced autofluorescence.[2] The recent development of lanthanide-doped nanophosphors that function in the near-infrared (NIR) spectral range optimal for optical transmission through biological tissues (650–900 nm) has attracted great interest towards in vivo bioimaging probes.[3–5] Alternatively, high-energy radiation, currently employed in medical imaging modalities, such as X-ray computed tomography (CT) or positron emission tomo graphy (PET), may also be used to excite NIR-emitting radioluminescent nanophosphors (RLNPs) for bioimaging.Recently, RLNPs have been proposed as molecular imaging probes in the development of combined X-ray/optical imaging modalities, such as X-ray luminescence computed tomography (XLCT).[6–8] This innovative imaging technique provides deep tissue penetration, circumvents tissue autofluorescence, and simplifies imaging through optical reconstruction from planar images. Tissue-specific accumulation of these RLNPs through molecular targeting strategies [9, 10] would allow for localization of lesions, such as tumors, through detection of luminescence induced by narrowly collimated X-rays. In addition, RLNPs capable of activation by radioisotopes, such as PET tracers and radiopharmaceuticals, may enable planar optical detection of radiotherapy or co-localization of molecular targets. To enable these novel imaging modalities, we present a facile procedure to synthesize poly (ethylene glycol)(PEG)-coated RLNPs and examine their ability to serve as optical probes excited by X-rays or radioisotopes.
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影响因子：
3.8
作者：
Carpenter, C. M.;Sun, C.;Xing, L.
通讯作者：
Xing, L.
影响因子：
3.6
作者：
Pratx, Guillem;Carpenter, Colin M.;Xing, Lei
通讯作者：
Xing, Lei
影响因子：
7.4
作者：
ROSS, HH
通讯作者：
ROSS, HH
影响因子：
3.7
作者：
Liu H;Ren G;Miao Z;Zhang X;Tang X;Han P;Gambhir SS;Cheng Z
通讯作者：
Cheng Z
影响因子：
8.6
作者：
Vetrone, Fiorenzo;Mahalingam, Venkataramanan;Capobianco, John A.
通讯作者：
Capobianco, John A.