Effects of oral contraceptive pills on mood and magnetic resonance imaging measures of prefrontal cortical thickness.
Effects of oral contraceptive pills on mood and magnetic resonance imaging measures of prefrontal cortical thickness.
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DOI：
10.1038/s41380-020-00990-2
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发表时间：
2021-03
影响因子：
11
通讯作者：
London ED
中科院分区：
文献类型：
--
作者：
Petersen N;Kearley NW;Ghahremani DG;Pochon JB;Fry ME;Rapkin AJ;London ED
性腺激素影响神经元的组织和可塑性。然而，美国大多数育龄妇女使用的避孕药改变其浓度的后果尚不清楚。横断面研究发现，与自然骑自行车的女性相比，使用口服避孕药（OCPs）的女性的皮质区域更大和更小，同时也有各种情绪变化。因此，本研究的目的是确定OCPs是否对可能影响情绪调节的前额叶皮质脑结构的MRI测量结果有影响。我们进行了一项双盲、安慰剂对照、随机交叉研究，比较了OCP（0.15 mg左炔诺孕酮+ 0.30 μg炔雌醇）与安慰剂（N = 26）对前额叶皮质厚度MRI测量值和情绪的影响，如每日问题严重程度记录中的自我报告所示，其中还包括一项与躯体症状相关的项目。与安慰剂组相比，OCP组双侧三角部、盖部和右半球额极的反映皮质厚度的MRI测量值较小。只有右侧三角部的效应在多重比较校正后存活。右侧三角区皮质厚度的MRI测量与情绪症状无关，但与DSRP上躯体症状的严重程度呈负相关。的躯体症状和MRI措施可能是独立的类固醇激素在OCPs的行动，与OCPs同时诱导更多的影响MRI测量皮质厚度和躯体症状。
Gonadal hormones influence neuronal organization and plasticity. Yet the consequences of altering their concentrations by administering contraceptive agents, which are used by most reproductive-age women in the United States, are unclear. Cross-sectional studies have found both larger and smaller cortical regions alongside a variety of mood alterations in women who use oral contraceptive pills (OCPs) compared to naturally-cycling women. The goal of this study, therefore, was to determine whether there is an effect of OCPs on MRI measures of prefrontal cortical brain structure that may influence regulation of mood. We performed a double-blind, placebo-controlled, randomized crossover study comparing effects of OCPs (0.15 mg levonorgestrel + 0.30 μg ethinyl estradiol) vs placebo (N = 26) on MRI measures of prefrontal cortical thickness and on mood, as indicated by self-report on the Daily Record of Severity of Problems, which also includes one item related to somatic symptoms. MRI measures that reflect cortical thickness were smaller bilaterally in the pars triangularis and in the pars opercularis and frontal pole of the right hemisphere during the OCP arm vs. placebo. Only the effect in the right pars triangularis survived multiple comparisons correction. Right pars triangularis MRI measures of cortical thickness were not related to mood symptoms, but negatively correlated across conditions with severity of somatic symptoms on the DSRP. The somatic symptoms and MRI measures may be independently related to the actions of steroid hormones in OCPs, with OCPs simultaneously inducing both more effects on MRI measures of cortical thickness and somatic symptoms.
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影响因子：
2.9
作者：
HOOGLAND, HJ;SKOUBY, SO
通讯作者：
SKOUBY, SO
影响因子：
4.5
作者：
Cheslack-Postava, Keely;Keyes, Katherine M.;Koenen, Karestan C.
通讯作者：
Koenen, Karestan C.
影响因子：
5
作者：
Hantsoo, Liisa;Epperson, C. Neill
通讯作者：
Epperson, C. Neill
影响因子：
2.9
作者：
DANFORTH, DR;HODGEN, GD
通讯作者：
HODGEN, GD
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y