Defective natural killer (NK) cell‐mediated cytotoxicity does not imply clonal involvement of NK cells in myelodysplastic syndromes
Defective natural killer (NK) cell‐mediated cytotoxicity does not imply clonal involvement of NK cells in myelodysplastic syndromes
复制标题
有缺陷的自然杀伤 (NK) 细胞介导的细胞毒性并不意味着 NK 细胞克隆参与骨髓增生异常综合征
DOI：
--
复制
发表时间：
1994
影响因子：
6.5
通讯作者：
T. Nomura
中科院分区：
文献类型：
--
作者：
K. Ogata;H. Fuju;N. Yokose;E. An;H. Tamura;K. Kamikubo;K. Dan;H. Hamaguchi;H. Sakamaki;Y. Onozawa;T. Nomura
总结。通过对10例骨髓增生异常综合征(MDS)患者的磷酸甘油酸激酶基因的限制性片段长度多态性和甲基化模式的分析，检测了纯化细胞的克隆性。同时检测自然杀伤细胞(NK细胞)介导的细胞毒作用。除1例单核细胞外，其余粒细胞和单核细胞均为单克隆性或寡克隆性。相反，大多数病例的NK和T细胞呈多克隆模式，包括所有具有缺陷的NK细胞介导的细胞毒作用的病例。MDS中NK细胞介导的细胞毒性降低是由NK细胞的克隆性参与引起的这一假说不被本研究支持。
SUMMARY. The clonality of purified cells was examined in 10 myelodysplastic syndromes (MDS) patients by analysing the restriction fragment length polymorphism and methylation pattern of the phosphoglycerate‐kinase gene. Natural killer (NK) cell‐mediated cytotoxicity was also examined. The granulocytes and monocytes were monoclonal or oligoclonal in all cases, except for the monocytes in one case. Conversely, the NK and T cells had a polyclonal pattern in most cases, including all cases who had defective NK cellmediated cytotoxicty. The hypothesis that reduced NK cellmediated cytotoxicity in MDS is caused by a clonal involvement of NK cells was not supported by the present study.
影响因子：
11.2
作者：
B. Vogelstein;E. Fearon;S. Hamilton;A. C. Preisinger;H. Willard;A. Michelson;A. Riggs;S. Orkin
通讯作者：
B. Vogelstein;E. Fearon;S. Hamilton;A. C. Preisinger;H. Willard;A. Michelson;A. Riggs;S. Orkin
影响因子：
20.3
作者：
Jeffrey S. Miller;C. Verfaillie;P. Mcglave
通讯作者：
Jeffrey S. Miller;C. Verfaillie;P. Mcglave