Neural correlates of STN DBS-induced cognitive variability in Parkinson disease.
Neural correlates of STN DBS-induced cognitive variability in Parkinson disease.
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DOI：
10.1016/j.neuropsychologia.2008.07.012
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发表时间：
2008-11
期刊：
影响因子：
2.6
通讯作者：
Hershey T
中科院分区：
文献类型：
--
作者：
Campbell MC;Karimi M;Weaver PM;Wu J;Perantie DC;Golchin NA;Tabbal SD;Perlmutter JS;Hershey T
虽然深部脑刺激丘脑下核（STN DBS）改善帕金森病（PD）的运动功能，但它对工作记忆（WM）和反应抑制（RI）表现的影响是可变的。本研究的目的是确定STN - dbs诱导的认知表现变异性的神经相关性。我们测量了双侧STN dbs诱导的辅助运动区（SMA）、背外侧前额叶皮层（DLPFC）、前扣带皮层（ACC）和右下额叶皮层（rIFC）的血流变化（PET和[15O]-水在一天内），以及已发表的meta分析定义的探索性roi。对24名PD参与者进行STN dbs诱导的WM和RI变化（空间延迟反应和第二天Go-No-Go）的测量。在这两天，参与者不服用PD药物过夜，并以平衡、双盲的方式给药。正如预测的那样，STN dbs诱导的DLPFC血流变化与WM变化相关，但与RI表现无关。此外，ACC血流变化与RI变化相关，而与WM表现无关。在这两种关系中，STN DBS反应时血流量增加与认知能力下降有关。在探索区域中，只有DLPFC和ACC的血流变化与表现相关。这些结果表明，STN DBS对认知表现影响的变异性与STN DBS诱导的DLPFC和ACC皮质血流变化有关。这种关系强调需要进一步了解介导STN DBS神经和认知反应变异性的因素。
Although deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson disease (PD) improves motor function, it has variable effects on working memory (WM) and response inhibition (RI) performance. The purpose of this study was to determine the neural correlates of STN DBS-induced variability in cognitive performance. We measured bilateral STN DBS-induced blood flow changes (PET and [15O]-water on one day) in the supplementary motor area (SMA), dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC), and right inferior frontal cortex (rIFC) as well as in exploratory ROIs defined by published meta-analyses. STN DBS-induced WM and RI changes (Spatial Delayed Response and Go-No-Go on the next day) were measured in 24 PD participants. On both days, participants withheld PD medications overnight and conditions (OFF v. ON) were administered in a counterbalanced, double-blind manner. As predicted, STN DBS-induced DLPFC blood flow change correlated with change in WM, but not RI performance. Furthermore, ACC blood flow change correlated with change in RI but not WM performance. For both relationships, increased blood flow related to decreased cognitive performance in response to STN DBS. Of the exploratory regions, only blood flow changes in DLPFC and ACC were correlated with performance. These results demonstrate that variability in the effects of STN DBS on cognitive performance relates to STN DBS-induced cortical blood flow changes in DLPFC and ACC. This relationship highlights the need to further understand the factors that mediate the variability in neural and cognitive response to STN DBS.
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