The association of walking pace and incident heart failure and subtypes among postmenopausal women.
The association of walking pace and incident heart failure and subtypes among postmenopausal women.
复制标题
DOI：
10.1111/jgs.17657
复制
发表时间：
2022-05
影响因子：
6.3
通讯作者：
Eaton, Charles B.
中科院分区：
文献类型：
--
作者：
Miremad, Moafi-Madani;Lin, Xiaochen;Rasla, Somwail;El Meligy, Amr;Roberts, Mary B.;Laddu, Deepika;Allison, Matthew;Martin, Lisa W.;Shadyab, Aladdin H.;Manson, Jo Ann E.;Chlebowski, Rowan;Panjrath, Gurusher;LaMonte, Michael J.;Liu, Simin;Eaton, Charles B.
探讨步行速度与心力衰竭风险及心力衰竭亚型之间的关系。我们在25,183名年龄在50-79岁的绝经后妇女中，研究了自我报告的步行速度与发生HF和HF亚型保留(HFpEF)和减少(HFrEF)射血分数之间的关系。在1993-1998年加入妇女健康倡议队列时，这一子组妇女没有心力衰竭、癌症或不能走一个街区，并自我报告了关于步行速度和步行持续时间的信息。采用多变量Cox回归分析步行速度(随意步速2英里/小时，平均步速2-3英里/小时，快速步速3英里/小时)与发生心衰的关系。我们还研究了步行速度和持续时间与发生心衰的联合关系。在中位数16.9年的随访中，有1455例事件判决的急性失代偿性心衰住院病例。步行速度与总体心力衰竭风险呈显著负相关(平均步行与休闲步行的HR=0.73，95%CI[0.65，0.83]；快速步行与休闲步行的HR=0.66，95%CI[0.56，0.78]。步行速度与HFpEF的相关性相似(HR=0.73，95%CI[0.62，0.86]平均VS休闲；HR=0.63，95%CI[0.50，0.80]空腹VS休闲)，以及HFrEF(HR=0.72，95%CI[0.57，0.91]平均VS休闲；HR=0.74，95%CI[0.54，0.99]空腹VS休闲)。步行时间少于1小时/周的散步者和平均步行时间超过2小时/周的人患心力衰竭的风险相当。在绝经后妇女中，步行速度与总体心衰、肾小动脉射血分数和高频射血分数的风险呈负相关。增加老年人步行速度的干预措施是否会降低心力衰竭的风险，以及快节奏是否会补偿短时间的步行需要进一步研究。
To investigate the association between walking pace and the risk of heart failure (HF) and HF sub-types. We examined associations of self-reported walking pace with risk of incident HF and HF subtypes of preserved (HFpEF) and reduced (HFrEF) ejection fractions, among 25,183 postmenopausal women, ages 50-79 years. At enrollment into the Women’s Health Initiative cohort in 1993-1998, this subset of women was free of HF, cancer, or the inability to walk one block, with self-reported information on walking pace and walking duration. Multivariable Cox regression was used to examine associations of walking pace (casual <2 mph [referent], average 2-3 mph, and fast >3 mph) with incident HF. We also examined the joint association of walking pace and duration with incident HF. There were 1455 incident adjudicated acute decompensated HF hospitalization cases during a median of 16.9 years of follow-up. There was a strong inverse association between walking pace and overall risk of HF (HR=0.73, 95%CI [0.65, 0.83] for average vs casual walking; HR=0.66, 95%CI [0.56, 0.78] for fast vs casual walking. There were similar associations of walking pace with HFpEF (HR=0.73, 95%CI [0.62, 0.86] average vs casual; HR=0.63, 95%CI [0.50, 0.80] for fast vs casual), and with HFrEF (HR=0.72, 95%CI [0.57, 0.91] for average vs casual; HR=0.74, 95%CI [0.54, 0.99] for fast vs casual). The risk of HF associated with fast walking with less than 1 hour/week walking duration was comparable with the risk of HF among casual and average walkers with more than 2 hours/week walking duration. Walking pace was inversely associated with risks of overall HF, HFpEF, and HFrEF in postmenopausal women. Whether interventions to increase the walking pace in older adults will reduce HF risk, and whether fast pace will compensate for the short duration of walking warrants further study.
登录
查看更多内容
运转良好的老年人的步行速度缓慢和心血管死亡：前瞻性队列研究。
DOI：
10.1136/bmj.b4460
发表时间：
2009-11-10
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Dumurgier J;Elbaz A;Ducimetière P;Tavernier B;Alpérovitch A;Tzourio C
通讯作者：
Tzourio C
影响因子：
37.8
作者：
Eaton, Charles B.;Abdulbaki, Abdulrahman M.;Howard, Barbara V.
通讯作者：
Howard, Barbara V.
影响因子：
39.3
作者：
Fuelster, Susann;Tacke, Matthias;von Haehling, Stephan
通讯作者：
von Haehling, Stephan
影响因子：
3.7
作者：
Fielding, Roger A.;Guralnik, Jack M.;Rejeski, W. Jack
通讯作者：
Rejeski, W. Jack
影响因子：
13
作者：
Del Gobbo, Liana C.;Kalantarian, Shadi;Mozaffarian, Dariush
通讯作者：
Mozaffarian, Dariush