Neurosteroids in Schizophrenia: Pathogenic and Therapeutic Implications.
Neurosteroids in Schizophrenia: Pathogenic and Therapeutic Implications.
复制标题
DOI：
10.3389/fpsyt.2018.00073
复制
发表时间：
2018
影响因子：
4.7
通讯作者：
Yao JK
中科院分区：
文献类型：
--
作者：
Cai H;Cao T;Zhou X;Yao JK
Neurosteroids are a group of important endogenous molecules affecting many neural functions in the brain. Increasing evidence suggests a possible role of these neurosteroids in the pathology and symptomatology of schizophrenia (SZ) and other mental disorders. The aim of this review is to summarize the current knowledge about the neural functions of neurosteroids in the brain, and to evaluate the role of the key neurosteroids as candidate modulators in the etiology and therapeutics of SZ. The present paper provides a brief introduction of neurosteroid metabolism and distribution, followed by a discussion of the mechanisms underlying neurosteroid actions in the brain. The content regarding the modulation of the GABAA receptor is elaborated, given the considerable knowledge of its interactions with other neurotransmitter and neuroprotective systems, as well as its ameliorating effects on stress that may play a role in the SZ pathophysiology. In addition, several preclinical and clinical studies suggested a therapeutic benefit of neurosteroids in SZ patients, even though the presence of altered neurosteroid pathways in the circulating blood and/or brain remains debatable. Following treatment of antipsychotic drugs in SZ, therapeutic benefits have also been linked to the regulation of neurosteroid signaling. Specifically, the neurosteroids such as pregnenolone and dehydroepiandrosterone affect a broad spectrum of behavioral functions through their unique molecular characteristics and may represent innovative therapeutic targets for SZ. Future investigations in larger cohorts with long-term follow-ups will be required to ascertain the neuropsychopharmacological role of this yet unexploited class of neurosteroid agents.
登录
查看更多内容
非典型抗精神病药物针对多种应激相关代谢途径的治疗效果
影响因子：
6.8
作者：
Cai HL;Jiang P;Tan QY;Dang RL;Tang MM;Xue Y;Deng Y;Zhang BK;Fang PF;Xu P;Xiang DX;Li HD;Yao JK
通讯作者：
Yao JK
DOI：
10.1186/1744-9081-8-61
发表时间：
2012-12-19
期刊：
Behavioral and brain functions : BBF
影响因子：
--
作者：
Carta MG;Bhat KM;Preti A
通讯作者：
Preti A
DOI：
10.1016/0960-0760(90)90490-c
发表时间：
1990-11-20
影响因子：
4.1
作者：
BAULIEU, EE;ROBEL, P
通讯作者：
ROBEL, P
DOI：
10.1073/pnas.241503698
发表时间：
2001-11-20
影响因子：
11.1
作者：
Akwa, Y;Ladurelle, N;Baulieu, EE
通讯作者：
Baulieu, EE
影响因子：
1.9
作者：
Alessandri, Jean-Marc;Extier, Audrey;Lavialle, Monique
通讯作者：
Lavialle, Monique