Cancer risk in tuberculosis patients in a high endemic area.
Cancer risk in tuberculosis patients in a high endemic area.
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高流行区结核病患者的癌症风险。
DOI：
10.1186/s12885-021-08391-6
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发表时间：
2021-06-09
期刊：
影响因子：
3.8
通讯作者：
Ji DM
中科院分区：
文献类型：
--
作者：
Chen GL;Guo L;Yang S;Ji DM
结核病（TB）可能促进癌变。我们在中国结核病高发地区新疆进行了结核病与癌症关系的病例对照研究。2016年1月至2018年12月，共纳入新疆肿瘤医院住院患者45455例，分为恶性肿瘤组（n = 32539）和良性肿瘤组（n = 12916）。回顾性分析两组患者在癌症诊断前的活动性和既往结核患者。恶性肿瘤组肺结核比例（n = 1776, 5.46%）显著高于对照组（n = 175, 1.35%） （p < 0.0001）。恶性组中结核发病率最高的为非霍奇金淋巴瘤（16.74%），最低的为甲状腺癌（0.77%）。在调整年龄、性别和种族的多变量分析中，结核病仍然是所有癌症的独立危险因素(优势比（OR） 1.68；95%置信区间（CI） 1.43-1.97)。此外，结核病与非霍奇金淋巴瘤、子宫颈癌、食道癌、“其他”癌症、卵巢癌和乳腺癌的风险显著升高有关。此外，除了食管癌和淋巴瘤外，女性结核病患者患癌症的可能性高于男性（p < 0.0001）。结核病患者患癌症的风险较高。在对某些与结核病高发相关的癌症类型患者进行治疗前，应考虑结核病筛查策略。
Tuberculosis (TB) may facilitate carcinogenesis. We performed a case-control study of the association between TB and cancer in Xinjiang, a high TB endemic area of China. From January 2016 to December 2018, a total of 45,455 patients hospitalized in Xinjiang Cancer Hospital were consecutively enrolled and divided into a malignant tumor group (n = 32,539) and a benign tumor group (n = 12,916). Patients with active and previous TB before the diagnosis of cancer were retrospectively identified in the two groups. A significantly higher proportion of TB was found in the malignant tumor group (n = 1776, 5.46%) than in the control (benign tumor) group (n = 175, 1.35%) (p < 0.0001). The highest and lowest proportions of TB in the malignant group were in patients with non-Hodgkin’s lymphoma (16.74%) and thyroid cancer (0.77%), respectively. In multivariate analysis adjusting for age, sex, and ethnicity, TB remained an independent risk factor for all cancers (odds ratio (OR) 1.68; 95% confidence interval (CI) 1.43–1.97). Furthermore, TB was associated with a significantly higher risk of non-Hodgkin’s lymphoma, cervical cancer, esophageal cancer, “other” cancers, ovarian cancer, and breast cancer. Moreover, females with TB were more likely to develop cancer than males (p < 0.0001), except for esophageal cancer and lymphoma. TB patients have an elevated cancer risk. A screening strategy for TB should be taken into consideration before treatment in patients with some cancer types that are associated with a high proportion of TB.
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影响因子：
24.3
作者：
Hemminki, Kari;Liu, Xiangdong;Sundquist, Kristina
通讯作者：
Sundquist, Kristina
影响因子：
34.3
作者：
Mijiti, Peierdun;Li Yuehua;Upur, Halmurat
通讯作者：
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DOI：
10.1186/ar557
发表时间：
2002
期刊：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.21149/10090
发表时间：
2019-06-01
期刊：
Salud Pública de México
影响因子：
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作者：
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通讯作者：
Hernández-Pando, Rogelio
影响因子：
9
作者：
Cao, Shuhui;Li, Jingwen;Zhong, Hua
通讯作者：
Zhong, Hua