IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development.
IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development.
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DOI：
10.1084/jem.20032183
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发表时间：
2004-09-20
期刊：
影响因子：
--
通讯作者：
Singer A
中科院分区：
文献类型：
--
作者：
Yu Q;Erman B;Park JH;Feigenbaum L;Singer A
胸腺内T细胞的发育依赖于T细胞受体和细胞因子受体传递的信号。早期的CD4CD8−−(双阴性)胸腺细胞生存和增殖需要白细胞介素7受体(IL-7R)信号，但IL-7R信号通常在胸腺细胞发育的未成熟单阳性阶段消失。我们现在证明，IL-7R信号抑制转录因子Tcf-1、Lef-1和RoRγt的表达，这些转录因子是isp在胸腺中进行双阳性(DP)转换所必需的。此外，我们还证明了IL-7R信号也抑制了成熟外周T细胞中TCF-1和Lef-1的表达。因此，本工作在T细胞和胸腺细胞中发现了几个重要的IL-7R信号下游靶基因，为IL-7R信号抑制胸腺细胞发育提供了分子机制。我们得出结论，IL-7R信号下调了isp向DP转变所需的转录因子，因此必须在胸腺细胞发育的isp阶段终止。
Intrathymic T cell development depends on signals transduced by both T cell receptor and cytokine receptors. Early CD4−CD8− (double negative) thymocytes require interleukin (IL)-7 receptor (IL-7R) signals for survival and proliferation, but IL-7R signals are normally extinguished by the immature single positive (ISP) stage of thymocyte development. We now demonstrate that IL-7R signals inhibit expression of transcription factors TCF-1, LEF-1, and RORγt that are required for the ISP to double positive (DP) transition in the thymus. In addition, we demonstrate that IL-7R signals also inhibit TCF-1 and LEF-1 expression in mature peripheral T cells. Thus, the present work has identified several important downstream target genes of IL-7R signaling in T cells and thymocytes that provide a molecular mechanism for the inhibitory influence of IL-7R signaling on DP thymocyte development. We conclude that IL-7R signals down-regulate transcription factors required for the ISP to DP transition and so must be terminated by the ISP stage of thymocyte development.
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影响因子：
64.8
作者：
NEGISHI, I;MOTOYAMA, N;LOH, DY
通讯作者：
LOH, DY
影响因子：
4.4
作者：
He, YW;Beers, C;Bevan, MJ
通讯作者：
Bevan, MJ
影响因子：
4.4
作者：
Van de Wiele, CJV;Marino, JH;Teague, TK
通讯作者：
Teague, TK
影响因子：
30.5
作者：
Ioannidis, V;Beermann, F;Held, W
通讯作者：
Held, W
DOI：
10.1084/jem.184.3.1137
发表时间：
1996-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hattori N;Kawamoto H;Fujimoto S;Kuno K;Katsura Y
通讯作者：
Katsura Y