Approach avoidance training versus Sham in veterans with alcohol use disorder: protocol for a randomized controlled trial.
Approach avoidance training versus Sham in veterans with alcohol use disorder: protocol for a randomized controlled trial.
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在患有酒精疾病的退伍军人中，避免训练与假手术：随机对照试验的方案。
DOI：
10.1186/s12888-023-04961-z
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发表时间：
2023-07-12
期刊：
影响因子：
4.4
通讯作者：
Bomyea, J.
中科院分区：
文献类型：
--
作者：
Caudle, M. M.;Klaming, R.;Fong, C.;Harle, K.;Taylor, C.;Spadoni, A.;Bomyea, J.
关键词：
酒精使用障碍（AUD）在退伍军人中非常普遍，通常与其他精神疾病同时发生。临时证据支持使用避近训练（AAT）作为治疗AUD的辅助方案。避近训练是一种计算机传递的认知偏差修正形式，旨在针对酒精相关线索的内隐避近偏差。然而，到目前为止，AAT对改善门诊退伍军人样本和精神合并症患者AUD恢复结果的有效程度尚未得到充分研究。在这里，我们描述了一项双盲随机对照试验，AAT与对照条件（Sham）在完成门诊标准治疗的患有共病精神疾病的退伍军人中进行。目前接受门诊治疗的136名退伍军人将被招募参加这项平行组分配的随机对照试验。参与者将随机分为6周的AAT （n = 68）或假训练（n = 68），并结合常规护理。评估将在基线、基线后6周、3个月和6个月进行。主要结果变量将包括饮酒的功能后果。次要结果变量包括酒精摄入量和酒精方法偏倚的行为指标。一部分参与者（n = 51）还将完成功能磁共振成像（fMRI），以评估酒精方法偏倚评估期间的神经反应。本研究是第一个将AAT作为标准护理辅助治疗的随机对照试验，用于患有AUD和共病精神疾病的退伍军人。此外，行为和神经影像学数据将用于确定AAT针对酒精线索的接近偏差的程度。如果有效，AAT可能是一种有前途的低成本的辅助治疗选择。退伍军人酒精使用障碍的AAT研究ClinicalTrials.gov: NCT05372029;注册日期：5/9/2022。在线版本包含补充材料，可在10.1186/s12888-023-04961-z获得。
Alcohol use disorder (AUD) is highly prevalent and commonly co-occurs with other psychiatric disorders among Veterans. Provisional evidence supports the use of Approach Avoidance Training (AAT) - a form of computer-delivered cognitive bias modification designed to target implicit approach bias for alcohol-related cues - as an adjunctive program to treat AUD. However, the extent to which AAT is effective for improving AUD recovery outcomes in outpatient Veteran samples and those with psychiatric comorbidities has been understudied to date. Here we describe a double-blind randomized controlled trial of AAT versus a comparison condition (Sham) being conducted in Veterans with comorbid psychiatric conditions completing outpatient standard care. One hundred thirty-six Veterans currently receiving outpatient treatment for AUD will be recruited for this randomized controlled trial with parallel group assignment. Participants will be randomized to either 6 weeks of AAT (n = 68) or Sham (n = 68) training in conjunction with usual care. Assessments will occur at baseline and 6 weeks, 3 months, and 6 months post-baseline. Primary outcome variables will include functional consequences of drinking. Secondary outcome variables will include alcohol consumption, and behavioral indicators of alcohol approach bias. A subset of participants (n = 51) will also complete functional magnetic resonance imaging (fMRI) to assess neural response during an alcohol approach bias assessment. This study is the first randomized controlled trial of AAT administered as an adjunctive treatment to standard care in Veterans with AUD and comorbid psychiatric disorders. Additionally, behavioral and neuroimaging data will be used to determine the extent to which AAT targets approach bias for alcohol cues. If effective, AAT may be a promising low-cost adjunctive treatment option for individuals with AUD. AAT for Alcohol Use Disorder in Veterans. ClinicalTrials.gov: NCT05372029; Date of Registration: 5/9/2022. The online version contains supplementary material available at 10.1186/s12888-023-04961-z.
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