Neural Connectivity Subtypes Predict Discrete Attentional Bias Profiles Among Heterogeneous Anxiety Patients.
Neural Connectivity Subtypes Predict Discrete Attentional Bias Profiles Among Heterogeneous Anxiety Patients.
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DOI：
10.1177/2167702620906149
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发表时间：
2020-05-01
期刊：
影响因子：
--
通讯作者：
Siegle GJ
中科院分区：
文献类型：
--
作者：
Price RB;Beltz AM;Woody ML;Cummings L;Gilchrist D;Siegle GJ
平均而言，焦虑患者对威胁的注意力发生了改变，包括早期对威胁的警惕和后来对威胁的回避，并伴随着大脑各区域功能连接的改变。然而，在典型的组水平比较中，焦虑的临床、神经和注意力特征的实质异质性被忽视了。我们使用一种经过充分验证的方法对神经连接进行数据驱动解析，以揭示60名患有跨诊断焦虑的成年人中基于连接性的亚组。亚组进行外部比较的注意力模式来自独立的行为措施。出现了两个分组。亚组A（68%的患者）表现出更强的执行网络的影响，感觉处理区域和一个典范的“警惕-回避”模式的外部行为措施。亚组B的定义是边缘系统对感觉区域的影响更大，表现出更不典型和不一致的注意力。基于神经连通性的分类揭示了一个非典型的，边缘驱动模式的连接在一个子集的焦虑患者，推广到非典型模式的选择性注意。
On average, anxious patients show altered attention to threat—including early vigilance towards threat and later avoidance of threat—accompanied by altered functional connectivity across brain regions. However, substantial heterogeneity within clinical, neural, and attentional features of anxiety is overlooked in typical group-level comparisons. We used a well-validated method for data-driven parsing of neural connectivity to reveal connectivity-based subgroups among 60 adults with transdiagnostic anxiety. Subgroups were externally compared on attentional patterns derived from independent behavioral measures. Two subgroups emerged. Subgroup A (68% of patients) showed stronger executive network influences on sensory processing regions and a paradigmatic “vigilance-avoidance” pattern on external behavioral measures. Subgroup B was defined by a larger number of limbic influences on sensory regions and exhibited a more atypical and inconsistent attentional profile. Neural connectivity-based categorization revealed an atypical, limbic-driven pattern of connectivity in a subset of anxious patients that generalized to atypical patterns of selective attention.
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DOI：
10.1176/appi.ajp.2015.14091200
发表时间：
2016-04-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Clementz BA;Sweeney JA;Hamm JP;Ivleva EI;Ethridge LE;Pearlson GD;Keshavan MS;Tamminga CA
通讯作者：
Tamminga CA
影响因子：
25.8
作者：
Kaiser, Roselinde H.;Andrews-Hanna, Jessica R.;Wager, Tor D.;Pizzagalli, Diego A.
通讯作者：
Pizzagalli, Diego A.
影响因子：
82.9
作者：
Drysdale AT;Grosenick L;Downar J;Dunlop K;Mansouri F;Meng Y;Fetcho RN;Zebley B;Oathes DJ;Etkin A;Schatzberg AF;Sudheimer K;Keller J;Mayberg HS;Gunning FM;Alexopoulos GS;Fox MD;Pascual-Leone A;Voss HU;Casey BJ;Dubin MJ;Liston C
通讯作者：
Liston C
影响因子：
2.9
作者：
De Raedt, Rudi;Koster, Ernst H. W.
通讯作者：
Koster, Ernst H. W.
影响因子：
25.8
作者：
Grisanzio, Katherine A.;Goldstein-Piekarski, Andrea N.;Williams, Leanne M.
通讯作者：
Williams, Leanne M.