Redox Control of Signalling Responses to Contractile Activity and Ageing in Skeletal Muscle.
Redox Control of Signalling Responses to Contractile Activity and Ageing in Skeletal Muscle.
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作者：
近40年的研究已经确定，活性氧在骨骼肌的不同部位产生，并且这些物质的产生通过各种形式的运动而增加。最初，这被认为对骨骼肌和其他组织有潜在的有害作用，但最近的数据已经确定了这些物种在肌肉适应运动中的关键作用。本次审查的目的是总结我们目前的理解，这些氧化还原信号的作用，活性氧介导的肌肉收缩活动的反应，特别关注这些过程中的老化的影响。此外，我们提供的证据表明，从年龄相关的肌纤维去神经支配导致的肌肉线粒体的氧化还原状态的中断可能是一个重要因素，导致一些肌肉收缩活动的反应衰减，我们推测潜在的机制。
Research over almost 40 years has established that reactive oxygen species are generated at different sites in skeletal muscle and that the generation of these species is increased by various forms of exercise. Initially, this was thought to be potentially deleterious to skeletal muscle and other tissues, but more recent data have identified key roles of these species in muscle adaptations to exercise. The aim of this review is to summarise our current understanding of these redox signalling roles of reactive oxygen species in mediating responses of muscle to contractile activity, with a particular focus on the effects of ageing on these processes. In addition, we provide evidence that disruption of the redox status of muscle mitochondria resulting from age-associated denervation of muscle fibres may be an important factor leading to an attenuation of some muscle responses to contractile activity, and we speculate on potential mechanisms involved.
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影响因子：
5.3
作者：
Martinez Guimera A;Welsh CM;Proctor CJ;McArdle A;Shanley DP
通讯作者：
Shanley DP
DOI：
10.1080/13510002.2017.1416773
发表时间：
2018-12
期刊：
Redox report : communications in free radical research
影响因子：
--
作者：
Beyfuss K;Hood DA
通讯作者：
Hood DA
影响因子：
7.4
作者：
Collins, John A.;Wood, Scott T.;Loeser, Richard F.
通讯作者：
Loeser, Richard F.
影响因子：
4.8
作者：
Broome, Caroline S.;Kayani, Anna C.;McArdle, Anne
通讯作者：
McArdle, Anne
DOI：
10.18632/aging.101358
发表时间：
2018-01-04
期刊：
Aging
影响因子：
--
作者：
Del Campo A;Contreras-Hernández I;Castro-Sepúlveda M;Campos CA;Figueroa R;Tevy MF;Eisner V;Casas M;Jaimovich E
通讯作者：
Jaimovich E