Relationship Between Remnant Pancreatic Volume and Endocrine Function After Pancreaticoduodenectomy
Relationship Between Remnant Pancreatic Volume and Endocrine Function After Pancreaticoduodenectomy
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胰十二指肠切除术后残胰体积与内分泌功能的关系
DOI：
10.1177/0003134821989049
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Murakami Masahiko
中科院分区：
文献类型：
--
作者：
Yamazaki Tatsuya;Aoki Takeshi;Tashiro Yoshihiko;Koizumi Tomotake;Kusano Tomokazu;Matsuda Kazuhiro;Fujimori Akira;Yamada Kosuke;Nogaki Koji;Hakozaki Tomoki;Wada Yusuke;Shibata Hideki;Tomioka Kodai;Enami Yuta;Murakami Masahiko
背景胰腺体积减小是手术后糖尿病（DM）的预测因素。关于PV和手术前后内分泌功能的报道很少。我们研究了PV与胰岛素分泌的相关性。方法对17例行胰十二指肠切除术（PD）的患者进行术前、术后PV和c肽指数（CPI）测定。此外，还分析了PV与CPI的相关性。结果术前平均PV （PPV）为55.1±31.6 mL，术后残余PV （RPV）为25.3±17.3 mL， PV降低53%。术前c肽免疫反应（CPR）平均值为1.39±。术后CPR为0.85±0.51。术前平均CPI为1.29±。72，术后CPI为。73±0.48。RPV与CPR后（ρ = .507, P = .03）和CPI后（ρ = .619, P = .008）存在显著相关性。讨论PD后RPV与CPI有显著相关性。较小的RPV导致较低的胰岛素分泌能力，增加PD后新发DM的潜在风险。
BackgroundDecreased pancreatic volume (PV) is a predictive factor for diabetes mellitus (DM) after surgery. There are few reports on PV and endocrine function pre- and post-surgery. We investigated the correlation between PV and insulin secretion.MethodsSeventeen patients underwent pancreaticoduodenectomy (PD) Pre- and post-surgery PV and C-peptide index (CPI) measurements were performed. Additionally, the correlation between PV and CPI was analyzed.ResultsThe mean preoperative PV (PPV) was 55.1 ± 31.6 mL, postoperative remnant PV (RPV) was 25.3±17.3 mL, and PV reduction was 53%. The mean preoperative C-peptide immunoreactivity (CPR) was 1.39 ± .51 and postoperative CPR was .85±.51. The mean preoperative CPI was 1.29±.72 and postoperative CPI was .73 ± .48. Significant correlations were observed between RPV and post CPR (ρ = .507, P = .03) and post CPI (ρ = .619, P = .008).DiscussionThere was a significant correlation between RPV and CPI after PD. A smaller RPV resulted in lower insulin secretion ability, increasing the potential risk of new-onset DM after PD.
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DOI：
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发表时间：
1980
期刊：
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
Slezak, LA;Andersen, DK
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